Single-molecule diffusion study of activated EGFR implicates its endocytic pathway
文献类型：期刊论文
| 作者 | Xiao, Zeyu; Zhang, Wei; Yang, Yong; Xu, Li; Fang, Xiaohong |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2008-05-02 |
| 卷号 | 369期号:2页码:730-734 |
| 关键词 | Single-molecule Study Fluorescence Egfr Diffusion Endocytosis |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2008.02.084 |
| 英文摘要 | In this work, we have imaged the lateral diffusion of activated epidermal growth factor receptor (EGFR) on cell membrane for studying its internalization pathway. After EGF activation, the mobility of individual EGFR molecules was measured and compared with that in the cells disrupted of clathrin-coated pits and caveolae, the two endocytosis-competent membrane microdomains. The results implicated that activated EGFR molecules associated with clathrin-coated pits but not caveolae at low doses of EGF, whereas they were located in these two domains at high EGF doses. It provided supporting evidence for the occurrence of both clathrin-dependent and caveolae-dependent EGFR endocytosis. (c) 2008 Elsevier Inc. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000254676900074 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/63807]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Fang, Xiaohong |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Zeyu,Zhang, Wei,Yang, Yong,et al. Single-molecule diffusion study of activated EGFR implicates its endocytic pathway[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,369(2):730-734. |
| APA | Xiao, Zeyu,Zhang, Wei,Yang, Yong,Xu, Li,&Fang, Xiaohong.(2008).Single-molecule diffusion study of activated EGFR implicates its endocytic pathway.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,369(2),730-734. |
| MLA | Xiao, Zeyu,et al."Single-molecule diffusion study of activated EGFR implicates its endocytic pathway".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 369.2(2008):730-734. |
入库方式： OAI收割
来源：化学研究所
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