Binding of V-IV to human transferrin: Potential relevance to anticancer activity of vanadocene dichloride
文献类型：期刊论文
| 作者 | Du, Hongyan1,2; Xiang, Junfeng1; Zhang, Yazhou1,2; Tang, Yalin1; Xu, Guangzhi1 |
| 刊名 | JOURNAL OF INORGANIC BIOCHEMISTRY
 |
| 出版日期 | 2008 |
| 卷号 | 102期号:1页码:146-149 |
| ISSN号 | 0162-0134 |
| 关键词 | Transferrin Vanadocene Dichloride Targeting Delivery Antitumor Activity |
| DOI | 10.1016/j.jinorgbio.2007.07.030 |
| 英文摘要 | The action mechanism of vanadocene dichloride, Cp2VCl2 (CP = eta(5)-C5H5), has been investigated by interaction with human serum transferrin for its promising antitumor activities. Our results have shown that Cp2VCI2, binds to transferrin and form a new complex, and the calculated apparent association constant is 1.37 x 10(5) M-1 from the fluorescence quenching. Simultaneously, the variation of the secondary structure of transferrin occurs, most probably due to the coordination of the amino residues of protein with V-IV. It was evidenced that Cp is released free in solution after V-IV binding to transferrin by H-1 NMR measurements. These results have shown that Cp2VCl2, forms a complex with transferrin, which may provide a possible pathway in the transport and targeted delivery of the antitumor agent. (c) 2007 Elsevier Inc. All rights reserved. |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE INC |
| WOS记录号 | WOS:000252523200015 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/63957]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Tang, Yalin |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci,BNLMS, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Hongyan,Xiang, Junfeng,Zhang, Yazhou,et al. Binding of V-IV to human transferrin: Potential relevance to anticancer activity of vanadocene dichloride[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2008,102(1):146-149. |
| APA | Du, Hongyan,Xiang, Junfeng,Zhang, Yazhou,Tang, Yalin,&Xu, Guangzhi.(2008).Binding of V-IV to human transferrin: Potential relevance to anticancer activity of vanadocene dichloride.JOURNAL OF INORGANIC BIOCHEMISTRY,102(1),146-149. |
| MLA | Du, Hongyan,et al."Binding of V-IV to human transferrin: Potential relevance to anticancer activity of vanadocene dichloride".JOURNAL OF INORGANIC BIOCHEMISTRY 102.1(2008):146-149. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。