Synthesis and anti-hyperlipidemic activity of a novel starch piperinic ester
文献类型：期刊论文
| 作者 | Han, Jingfen1,2; Borjihan, Gereltu1,2; Bai, Ruke2; Sun, Zharigetu1; Bao, Narisu1; Chen, Xuesi3; Jing, Xiabin3 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2008-02-08 |
| 卷号 | 71期号:3页码:441-447 |
| 关键词 | Polysaccharide Starch Piper Longum L. Anti-hyperlipidemia Piperidine Piperinic Ester |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2007.06.014 |
| 英文摘要 | A novel starch piperinic ester (SPE) with anti-hyperlipidemia activity was synthesized by coupling a carboxylic group of piperic acid and a hydroxyl group on the backbone of starch. The synthetic process includes three steps. Firstly, piperic acid was obtained by hydrolyzing Piperine that was extracted from seeds of Piper longum L. (traditional medicine of Mongolian). Then, piperic acid was reacted with Carbonyldiimidazole (CDI) in DMSO under N-2 at 70 degrees C for 4 h. Finally, starch piperinic ester was obtained by the reaction of activated piperic acid with water soluble starch at 80 degrees C under N-2 for 24 h. The structure of the novel copolymer was characterized by FTIR, C-13 NMR and H-1 NMR. Anti-hyperlipidemic activity of SPE was assayed by pharmacological testes and the results indicated that the SPE had high anti-hyperlipidemic activity and would be one kind of new potential candidate of anti-hyperlipidemia pro-drug. (C) 2007 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000253093500012 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/64011]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Borjihan, Gereltu |
| 作者单位 | 1.Inner Mongolian Univ, Coll Chem & Chem Engn, Inst Polymer Sci, Inner Mongolia 010021, Peoples R China 2.Univ Sci & Technol China, Dept Polymer Sci & Engn, Hefei 230026, Anhui, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Jingfen,Borjihan, Gereltu,Bai, Ruke,et al. Synthesis and anti-hyperlipidemic activity of a novel starch piperinic ester[J]. CARBOHYDRATE POLYMERS,2008,71(3):441-447. |
| APA | Han, Jingfen.,Borjihan, Gereltu.,Bai, Ruke.,Sun, Zharigetu.,Bao, Narisu.,...&Jing, Xiabin.(2008).Synthesis and anti-hyperlipidemic activity of a novel starch piperinic ester.CARBOHYDRATE POLYMERS,71(3),441-447. |
| MLA | Han, Jingfen,et al."Synthesis and anti-hyperlipidemic activity of a novel starch piperinic ester".CARBOHYDRATE POLYMERS 71.3(2008):441-447. |
入库方式： OAI收割
来源：化学研究所
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