A generally adoptable radiotracing method for tracking carbon nanotubes in animals
文献类型：期刊论文
| 作者 | Deng, Xiaoyong1,2; Yang, Shengtao1; Nie, Haiyu1; Wang, Haifang1; Liu, Yuanfang1,2 |
| 刊名 | NANOTECHNOLOGY
 |
| 出版日期 | 2008-02-20 |
| 卷号 | 19期号:7 |
| ISSN号 | 0957-4484 |
| DOI | 10.1088/0957-4484/19/7/075101 |
| 英文摘要 | Carbon nanotube (CNT) mediated drug delivery systems have currently aroused a great deal of interest. Such delivery systems for drugs, proteins and genes have been preliminarily studied using cellular and animal models. For the further study of the pharmacokinetics and related biological behaviours of CNTs in vivo, a fast and convenient tracing method is particularly demanded. In this paper, we developed a generally adoptable tracing method for the biodistribution study of functionalized CNTs in vivo. Taurine covalently functionalized multi-walled carbon nanotubes (tau-MWNTs) and Tween-80 wrapped MWNTs (Tween-MWNTs) were labelled with (125)I, and then their distribution in mice was determined. It is interesting that Tween-80 can reduce the RES uptake of MWNTs remarkably. The resulting distribution of (125)I-tau-MWNTs was very consistent with that using (14)C-taurine-MWNTs as the CNTs tracer, which means the easy (125)I labelling method is reliable and effective. |
| 语种 | 英语 |
| WOS记录号 | WOS:000252967300001 |
| 出版者 | IOP PUBLISHING LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/64103]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Haifang |
| 作者单位 | 1.Peking Univ, Dept Biol Chem, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Xiaoyong,Yang, Shengtao,Nie, Haiyu,et al. A generally adoptable radiotracing method for tracking carbon nanotubes in animals[J]. NANOTECHNOLOGY,2008,19(7). |
| APA | Deng, Xiaoyong,Yang, Shengtao,Nie, Haiyu,Wang, Haifang,&Liu, Yuanfang.(2008).A generally adoptable radiotracing method for tracking carbon nanotubes in animals.NANOTECHNOLOGY,19(7). |
| MLA | Deng, Xiaoyong,et al."A generally adoptable radiotracing method for tracking carbon nanotubes in animals".NANOTECHNOLOGY 19.7(2008). |
入库方式： OAI收割
来源：化学研究所
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