Organophosphonate functionalized Gd@C-82 as a magnetic resonance imaging contrast agent
文献类型：期刊论文
| 作者 | Shu, Chun-Ying1; Wang, Chun-Ru1; Zhang, Jian-Fei2; Gibson, Harry W.2; Dorn, Harry C.2; Corwin, Frank D.3; Fatouros, Panos P.3; Dennis, T. John S.4 |
| 刊名 | CHEMISTRY OF MATERIALS
 |
| 出版日期 | 2008-03-25 |
| 卷号 | 20期号:6页码:2106-2109 |
| ISSN号 | 0897-4756 |
| DOI | 10.1021/cm7023982 |
| 英文摘要 | A new magnetic resonance imaging contrast agent containing organophosphonate functional groups was synthesized in high yield by a simple synthesis procedure. This molecule exhibits much higher longitudinal water proton relaxivity (37.0 mM(-1) s(-1)) than commercial Omniscan (Gd-DTPA BMA, 5.7 mM(-1) s(-1)) at 0.35 T. Notably, the relaxivity is larger than that of carboxylated Gd@C-82 (16.0 mM(-1) s(-1)) under the same conditions, indicating that the functional groups have an important role on the image contrast enhancement. In addition, the introduction of phosphonate substituents may provide bone-targeting MRI contrast agents. |
| 语种 | 英语 |
| WOS记录号 | WOS:000254128800012 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/64309]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Chun-Ru |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China 2.Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24060 USA 3.Virginia Commonwealth Univ, Dept Radiol, Richmond, VA 23298 USA 4.Queen Mary Univ London, Ctr Mat Res, London E1 4NS, England |
| 推荐引用方式 GB/T 7714 | Shu, Chun-Ying,Wang, Chun-Ru,Zhang, Jian-Fei,et al. Organophosphonate functionalized Gd@C-82 as a magnetic resonance imaging contrast agent[J]. CHEMISTRY OF MATERIALS,2008,20(6):2106-2109. |
| APA | Shu, Chun-Ying.,Wang, Chun-Ru.,Zhang, Jian-Fei.,Gibson, Harry W..,Dorn, Harry C..,...&Dennis, T. John S..(2008).Organophosphonate functionalized Gd@C-82 as a magnetic resonance imaging contrast agent.CHEMISTRY OF MATERIALS,20(6),2106-2109. |
| MLA | Shu, Chun-Ying,et al."Organophosphonate functionalized Gd@C-82 as a magnetic resonance imaging contrast agent".CHEMISTRY OF MATERIALS 20.6(2008):2106-2109. |
入库方式： OAI收割
来源：化学研究所
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