Photobleaching of hypocrellin B and 2-taurine substituted hypocrellin B in plasma solution
文献类型：期刊论文
| 作者 | Ding Hui-Ying1; Zhang Yang2; Gu Ying1; Zhao Jing-Quan2 |
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2008-03-01 |
| 卷号 | 26期号:3页码:510-515 |
| 关键词 | Hypocrellin Singlet Oxygen Photobleaching Photodynamic Therapy |
| ISSN号 | 1001-604X |
| 英文摘要 | Photodynamic therapy (PDT) is a new methodology to utilize jointly a photosensitizer and light to destroy the target tissues of diseases via some photochemical reactions. On the other hand, the photosensitizer molecules may also be photo-bleached during PDT, furthermore, their interaction with biomolecules and the photobleaching properties in blood vessels are critical to treatments of microvascular diseases. In consideration of these, the photobleaching processes of HB and its analogue THB in plasma solutions were investigated in the current work. It was observed that the photobleaching was predominately mediated by singlet oxygen reactions in well-oxygenated aqueous solution in the presence of plasma substrate which not only greatly enhanced the photobleaching rate but also led to different photoproducts due to distinctly different reaction mechanisms. The relative photobleaching mechanisms were proposed based on the structural information and the redox potentials of the photosensitizers. |
| 语种 | 英语 |
| WOS记录号 | WOS:000254466500019 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/64327]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Ding Hui-Ying |
| 作者单位 | 1.Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing 100853, Peoples R China 2.Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Key Lab Photochem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding Hui-Ying,Zhang Yang,Gu Ying,et al. Photobleaching of hypocrellin B and 2-taurine substituted hypocrellin B in plasma solution[J]. CHINESE JOURNAL OF CHEMISTRY,2008,26(3):510-515. |
| APA | Ding Hui-Ying,Zhang Yang,Gu Ying,&Zhao Jing-Quan.(2008).Photobleaching of hypocrellin B and 2-taurine substituted hypocrellin B in plasma solution.CHINESE JOURNAL OF CHEMISTRY,26(3),510-515. |
| MLA | Ding Hui-Ying,et al."Photobleaching of hypocrellin B and 2-taurine substituted hypocrellin B in plasma solution".CHINESE JOURNAL OF CHEMISTRY 26.3(2008):510-515. |
入库方式： OAI收割
来源：化学研究所
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