Inhibition of acrylamide toxicity in mice by three dietary constituents
文献类型：期刊论文
| 作者 | Xie, Qunying1; Liu, Ye1; Sun, Hongfang1; Liu, Yuanfang1; Ding, Xingfang2; Fu, Dongpo2; Liu, Kexin2; Du, Xianmei3; Jia, Guang3 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2008-08-13 |
| 卷号 | 56期号:15页码:6054-6060 |
| 关键词 | Acrylamide-biomacromolecule Adducts Tea Polyphenol Resveratrol Diallyl Trisulfide Inhibition Creatine Kinase Glutathione S-transferase Accelerator Mass Spectrometry |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/jf0730542 |
| 英文摘要 | inhibitory effects of three dietary constituents, tea polyphenols, resveratrol, and diallyl trisulfide, on acrylamide-biomacromolecule (liver DNA, prolamine, and hemoglobin) adduct formation at human exposure level were studied by accelerator mass spectrometry. The results demonstrated that the three dietary constituents all significantly inhibited the formation of acrylamide adducts with liver DNA, whereas tea polyphenols and diallyl trisulfide reduced prolamine and hemoglobin adducts, respectively. Further biochemical studies showed that acrylamide could significantly inactivate creatine kinase and glutathione S-transferase and deplete glutathione. When the inhibitors were cotreated with acrylamide, all of them could effectively recover the activities of creatine kinase. In addition, tea polyphenols and diallyl trisulfide could increase glutathione S-transferase activity remarkably. On the basis of these results, mechanisms of the effects are discussed. This study might provide a beneficial guide to people's diet for the purpose of reducing the harmful effect of acrylamide. |
| 语种 | 英语 |
| WOS记录号 | WOS:000258270300012 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/64409]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Sun, Hongfang |
| 作者单位 | 1.Peking Univ, State Key Lab Nucl Phys & Technol, Coll Chem & Mol Engn, Dept Biol Chem,Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Peking Univ, Sch Phys, Inst Heavy Ion Phys, Beijing 100871, Peoples R China 3.Peking Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Beijing 100083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Qunying,Liu, Ye,Sun, Hongfang,et al. Inhibition of acrylamide toxicity in mice by three dietary constituents[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2008,56(15):6054-6060. |
| APA | Xie, Qunying.,Liu, Ye.,Sun, Hongfang.,Liu, Yuanfang.,Ding, Xingfang.,...&Jia, Guang.(2008).Inhibition of acrylamide toxicity in mice by three dietary constituents.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,56(15),6054-6060. |
| MLA | Xie, Qunying,et al."Inhibition of acrylamide toxicity in mice by three dietary constituents".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 56.15(2008):6054-6060. |
入库方式： OAI收割
来源：化学研究所
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