Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass Spectrometry combined with O-18-Labeling
文献类型：期刊论文
| 作者 | Wang, Fuyi2,3; Weidt, Stefan2; Xu, Jingjing2; Mackay, C. Logan2; Langridge-Smith, Pat R. R.2; Sadler, Peter J.1,2 |
| 刊名 | JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
 |
| 出版日期 | 2008-04-01 |
| 卷号 | 19期号:4页码:544-549 |
| ISSN号 | 1044-0305 |
| DOI | 10.1016/j.jasms.2007.12.002 |
| 英文摘要 | Reactions of the anticancer complex [(eta(6) -bip)Ru(en)Cl](+) (where bip is biphenyl and en is ethylenediamine) with the tripeptide glutathione (gamma-L-GIU-L-Cys-Gly; GSH), the abundant intracellular thiol, in aqueous solution give rise to two ruthenium cluster complexes, which could not be identified by electrospray mass spectrometry (ESI-MS) using a quadrupole mass analyzer. Here we use Fourier transform ion cyclotron mass spectrometry (nanoLC-FT-TCR MS) to identify the clusters separated by nanoscale liquid chromatography as the tetranuclear complex [ {eta(6) -bip)Ru(GSO(2))}(4)](2-) (2) and dinuclear complex [{eta(6) -bip)Ru(GSO(2))(2)}(2)](8-) (3) containing glutathione sulfinate (GSO(2)) ligands. Use of (OH2)-O-18 showed that oxygen from water can readily be incorporated into the oxidized glutathione ligands. These data illustrate the power of high-resolution MS for identifying highly charged multinuclear complexes and elucidating novel reaction pathways for metallodrugs, including ligand-based redox reactions. |
| 语种 | 英语 |
| WOS记录号 | WOS:000255091500009 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/64449]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Sadler, Peter J. |
| 作者单位 | 1.Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England 2.Univ Edinburgh, Sch Chem, Edinburgh, Midlothian, Scotland 3.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Fuyi,Weidt, Stefan,Xu, Jingjing,et al. Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass Spectrometry combined with O-18-Labeling[J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,2008,19(4):544-549. |
| APA | Wang, Fuyi,Weidt, Stefan,Xu, Jingjing,Mackay, C. Logan,Langridge-Smith, Pat R. R.,&Sadler, Peter J..(2008).Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass Spectrometry combined with O-18-Labeling.JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,19(4),544-549. |
| MLA | Wang, Fuyi,et al."Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass Spectrometry combined with O-18-Labeling".JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 19.4(2008):544-549. |
入库方式： OAI收割
来源：化学研究所
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