Novel aliphatic poly(ester-carhonate) with pendant allyl ester groups and its folic acid functionalization
文献类型：期刊论文
| 作者 | Hu, Xiuli1,2; Chen, Xuesi1; Liu, Shi1; Shi, Quan1,2; Jing, Xiabin1 |
| 刊名 | JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
 |
| 出版日期 | 2008-03-01 |
| 卷号 | 46期号:5页码:1852-1861 |
| 关键词 | Allyl Biocompatible Biodegradable Functionalization Of Polymers Polycarbonates |
| ISSN号 | 0887-624X |
| DOI | 10.1002/pola.22530 |
| 英文摘要 | A series of novel poly(ester-carbonate)s bearing pendant allyl ester groups P(LA-co-MAC)s were prepared by ring-opening copolymerization Of L-lactide (LA) and 5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one (MAC) with diethyl zinc (ZnEt2) as initiator. NMR analysis investigated the microstructure of the copolymer. DSC results indicated that the copolymers displayed a single glass-transition temperature (T-g), which was indicative of a random copolymer, and the Tg decreased with increasing carbonate content in the copolymer. Then NHS-activated folic acid (FA) first reacted with 2-aminoethanethiol to yield FA-SH; grafting FA-SH to P(LA-co-MAC) in the presence of TEA produced P(LA-co-MAC)/FA. The structure of P(LA-co-MAC)/FA and its precursor were confirmed by H-1 NMR and XPS analysis. Cell experiments showed that FA-grafted P(LA-co-MAC) had improved adhesion and proliferation behavior of vero cells on the polymer films. Therefore, the novel FA-grafted block copolymer is expected to find application in drug delivery or tissue engineering. (c) 2008 Wiley Periodicals, Inc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000253735200042 |
| 出版者 | JOHN WILEY & SONS INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/64497]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xiuli,Chen, Xuesi,Liu, Shi,et al. Novel aliphatic poly(ester-carhonate) with pendant allyl ester groups and its folic acid functionalization[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2008,46(5):1852-1861. |
| APA | Hu, Xiuli,Chen, Xuesi,Liu, Shi,Shi, Quan,&Jing, Xiabin.(2008).Novel aliphatic poly(ester-carhonate) with pendant allyl ester groups and its folic acid functionalization.JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,46(5),1852-1861. |
| MLA | Hu, Xiuli,et al."Novel aliphatic poly(ester-carhonate) with pendant allyl ester groups and its folic acid functionalization".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 46.5(2008):1852-1861. |
入库方式： OAI收割
来源：化学研究所
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