Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water
文献类型：期刊论文
| 作者 | Zhao, Changwen1,2; Zhuang, Xiuli1; He, Chaoliang1; Chen, Xuesi1; Jing, Xiabin1 |
| 刊名 | MACROMOLECULAR RAPID COMMUNICATIONS
 |
| 出版日期 | 2008-11-19 |
| 卷号 | 29期号:22页码:1810-1816 |
| 关键词 | Hydrophilic Polymers Ph Responsive Polypeptide Self-assembly Temperature Responsive |
| ISSN号 | 1022-1336 |
| DOI | 10.1002/marc.200800494 |
| 英文摘要 | A series of novel temperature and pH responsive block copolymers composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(L-lysine) (PLL) were synthesized. The effect of pH and the length of PLL on the lower critical solution temperature (LCST) of PNIPAM, and the self-assembly of these PLL-based copolymers induced by temperature and pH changes were investigated by the cloud point method, dynamic light scattering (DLS) and environmental scanning electron microscopy (ESEM). These PNIPAM-b-PLL copolymers can self-assemble into micelle-like aggregates with PNIPAM as the hydrophobic block at acidic pH and high temperatures; and at alkaline pH and low hey can self-assemble into temperatures, particles with PLL as the hydrophobic block. The copolymers may have potential applications in biotechnological and biomedical areas as drug release carriers. |
| 语种 | 英语 |
| WOS记录号 | WOS:000261544700005 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/64509]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhuang, Xiuli |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Changwen,Zhuang, Xiuli,He, Chaoliang,et al. Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water[J]. MACROMOLECULAR RAPID COMMUNICATIONS,2008,29(22):1810-1816. |
| APA | Zhao, Changwen,Zhuang, Xiuli,He, Chaoliang,Chen, Xuesi,&Jing, Xiabin.(2008).Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water.MACROMOLECULAR RAPID COMMUNICATIONS,29(22),1810-1816. |
| MLA | Zhao, Changwen,et al."Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water".MACROMOLECULAR RAPID COMMUNICATIONS 29.22(2008):1810-1816. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。