Micellization of Surfactin and Its Effect on the Aggregate Conformation of Amyloid beta(1-40)
文献类型：期刊论文
| 作者 | Han, Yuchun; Huang, Xu; Cao, Meiwen; Wang, Yilin |
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY B
 |
| 出版日期 | 2008-11-27 |
| 卷号 | 112期号:47页码:15195-15201 |
| ISSN号 | 1520-6106 |
| DOI | 10.1021/jp805966x |
| 英文摘要 | The aggregation of amyloid beta-peptide (A beta(1-40)) into fibrils is a key pathological process associated with Alzheimer's disease. This work has investigated the micellization process of biosurfactant surfactin and its effect on the aggregation behavior of A beta(1-40). The results show that surfactin has strong self-assembly ability to form micelles and the micelles tend to form larger aggregates. Surfactin adopts a beta-turn conformation at low micelle concentration but a beta-sheet conformation at high micelle concentration. The effect of surfactin on the A beta(1-40) aggregation behavior exhibits a strong concentration-dependent fashion. Below the critical micelle concentration of surfactin, the electrostatic binding of surfactin monomers on A beta(1-40) causes A beta(1-40) molecules to unfold. Assisted by the hydrophobic interaction among surfactin monomers on the A beta(1-40) chain, the conformation of A beta(1-40) transfers to the beta-sheet structure, which promotes the formation of fibrils. At low surfactin micelle concentration, besides the electrostatic force and hydrophobic interaction, hydrogen bonds formed between surfactin micelles and adjacent A beta(1-40) peptide chains may promote the ordered organization of these A beta(1-40) peptide chains, thus leading to the formation of beta-sheets and fibrils to a great extent. At high surfactin micelle concentration, the separating of A beta(1-40) chains by the excessive surfactin micelles and the aggregation of the complexes of A beta(1-40) with surfactin micelles inhibit the fort nation of beta-sheets and fibrils. |
| 语种 | 英语 |
| WOS记录号 | WOS:000261056400061 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/64701]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Yilin |
| 作者单位 | Chinese Acad Sci, Key Lab Colloid & Interface Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Yuchun,Huang, Xu,Cao, Meiwen,et al. Micellization of Surfactin and Its Effect on the Aggregate Conformation of Amyloid beta(1-40)[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2008,112(47):15195-15201. |
| APA | Han, Yuchun,Huang, Xu,Cao, Meiwen,&Wang, Yilin.(2008).Micellization of Surfactin and Its Effect on the Aggregate Conformation of Amyloid beta(1-40).JOURNAL OF PHYSICAL CHEMISTRY B,112(47),15195-15201. |
| MLA | Han, Yuchun,et al."Micellization of Surfactin and Its Effect on the Aggregate Conformation of Amyloid beta(1-40)".JOURNAL OF PHYSICAL CHEMISTRY B 112.47(2008):15195-15201. |
入库方式： OAI收割
来源：化学研究所
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