Preparation of temperature- and pH-sensitive PVME/CMCS hydrogels via electron beam irradiation cross-linking and their properties
文献类型：期刊论文
| 作者 | Yu Yang1; Yin Jing-Bo1; Luo Kun1; Xie Yong-Tao1; Yan Shi-Feng1; Ma Jia2; Chen Xue-Si2 |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2008-02-10 |
| 卷号 | 29期号:2页码:409-414 |
| 关键词 | Sensitivity Hydrogel Drug Release Poly(Vinyl Methyl Ether) Carboxymethylchitosan |
| ISSN号 | 0251-0790 |
| 英文摘要 | Hydrogels based on poly(vinyl methyl ether) (PVME) and carboxymethylchitosan (CMCS) were prepared with electron beam irradiation (EB) cross-linking at room temperature. The effects of temperature, pH, CMCS content on the swelling properties of PVME/CMCS hydrogels were studied. The release behavior of a drug was tentatively investigated as well. The results show that the gel fraction of PVME/CMCS blend gels increases rapidly and then levels off above the radiation dose of 40 kGy, and it decreases with the increase of CMCS content in PVME/CMCS system. The hydrogels are thermo- and pH-sensitive, and show a fast swelling reversibility. At pH < 3.0 and pH > 5.0, the hydrogels have a higher swelling ratio; however, the swelling ratio is relatively lower in the pH range of 3.0-5.0 due to the electrostatic force. Increasing CMCS content and decreasing irradiation dose can improve the drug loading. The release of 5-fluorouracil can be governed by regulating the CMCS content and irradiation dose. |
| 语种 | 英语 |
| WOS记录号 | WOS:000253139800041 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/64753]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yin Jing-Bo |
| 作者单位 | 1.Shanghai Univ, Coll Mat Sci, Dept Polymer Mat, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu Yang,Yin Jing-Bo,Luo Kun,et al. Preparation of temperature- and pH-sensitive PVME/CMCS hydrogels via electron beam irradiation cross-linking and their properties[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2008,29(2):409-414. |
| APA | Yu Yang.,Yin Jing-Bo.,Luo Kun.,Xie Yong-Tao.,Yan Shi-Feng.,...&Chen Xue-Si.(2008).Preparation of temperature- and pH-sensitive PVME/CMCS hydrogels via electron beam irradiation cross-linking and their properties.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,29(2),409-414. |
| MLA | Yu Yang,et al."Preparation of temperature- and pH-sensitive PVME/CMCS hydrogels via electron beam irradiation cross-linking and their properties".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 29.2(2008):409-414. |
入库方式： OAI收割
来源：化学研究所
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