The effect of Cu2+ on the interaction between an antitumor drug-mitoxantrone and human serum albumin
文献类型：期刊论文
| 作者 | Tian, Ming-Yue1,2; Zhang, Xiu-Feng1; Xie, Ling1; Xiang, Jun-Feng1; Tang, Ya-Lin1; Zhao, Chang-Qi2 |
| 刊名 | JOURNAL OF MOLECULAR STRUCTURE
 |
| 出版日期 | 2008-12-15 |
| 卷号 | 892期号:1-3页码:20-24 |
| 关键词 | Mitoxantrone Human Serum Albumin Cu2++++ Fluorescence Spectroscopy Circular Dichroism |
| ISSN号 | 0022-2860 |
| DOI | 10.1016/j.molstruc.2008.04.049 |
| 英文摘要 | The studies on the interaction between HSA and drugs have been an interesting research field in life sciences, chemistry and clinical medicine. There are also many metal ions present in blood plasma, thus the research about the effect of metal ions on the interaction between drugs and plasma proteins is crucial. In this study, we have investigated the effect of a familiar metal ion-Cu2+ on the interaction between an antitumor drug-mitoxantrone (MTO) and human serum albumin (HSA) by using fluorescence spectroscopy, ultraviolet-visible absorption spectroscopy and circular dichroism spectroscopy, for the first time. The results showed that the quenching efficiency of MTO to HSA is higher with Cu2+ than that without Cu2+. In the presence of Cu2+. the secondary structure of HSA was changed and the alpha-helix content was increased. The apparent association constant (K-A), the binding sites (n) and the spatial-distance (r) between MTO and HSA decreased. These results indicated that Cu2+ could affect the interaction between MTO and HSA by altering HSA molecular conformation. Further calculation indicated that the binding mode of Cu2+ in MTO-HSA system was likely to form Cu2+-HSA complex. (C) 2008 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000261711400004 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/64893]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Tang, Ya-Lin |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China 2.Beijing Normal Univ, Coll Life Sci, Beijing 100875, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Ming-Yue,Zhang, Xiu-Feng,Xie, Ling,et al. The effect of Cu2+ on the interaction between an antitumor drug-mitoxantrone and human serum albumin[J]. JOURNAL OF MOLECULAR STRUCTURE,2008,892(1-3):20-24. |
| APA | Tian, Ming-Yue,Zhang, Xiu-Feng,Xie, Ling,Xiang, Jun-Feng,Tang, Ya-Lin,&Zhao, Chang-Qi.(2008).The effect of Cu2+ on the interaction between an antitumor drug-mitoxantrone and human serum albumin.JOURNAL OF MOLECULAR STRUCTURE,892(1-3),20-24. |
| MLA | Tian, Ming-Yue,et al."The effect of Cu2+ on the interaction between an antitumor drug-mitoxantrone and human serum albumin".JOURNAL OF MOLECULAR STRUCTURE 892.1-3(2008):20-24. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。