Synthesis, herbicidal activities, and 3D-QSAR of 2-cyanoacrylates containing aromatic methylamine moieties
文献类型：期刊论文
| 作者 | Liu, Yu-Xiu1,2; Wei, Deng-Guo1; Zhu, Ye-Rong3; Liu, Shao-Hua2; Zhang, Yong-Lin2; Zhao, Qi-Qi2; Cai, Bao-Li2; Li, Yong-Hong2; Song, Hai-Bin2; Liu, Ying1 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2008-01-09 |
| 卷号 | 56期号:1页码:204-212 |
| 关键词 | Herbicides Photosynthetic Electron Transport Inhibitors 2-cyanoacrylates Aromatic Rings Comfa |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/jf072851x |
| 英文摘要 | A series of novel 2-cyanoacrylates containing different aromatic rings were synthesized, and their structures were characterized by H-1 NMR, elemental analysis, and single-crystal X-ray diffraction analysis. Their herbicidal activities against four weeds and inhibition of photosynthetic electron transport against isolated chloroplasts (the Hill reaction) were evaluated. Both in vivo and in vitro data showed that the compounds containing benzene, pyridine, and thiazole moieties gave higher activities than those containing pyrimidine, pyridazine, furan, and tetrahedronfuran moieties. To further explore the comprehensive structure-activity relationship on the basis of in vitro data, comparative molecular field analysis (CoMFA) was performed, and the results showed that a bulky and electronegative group around the para-position of the aromatic rings would have the potential for higher activity, which offered important structural insights into designing highly active compounds prior to the next synthesis. |
| 语种 | 英语 |
| WOS记录号 | WOS:000252059400028 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/65101]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Ying |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China 2.Nankai Univ, Inst Elementoorgan Chem, Tianjin Key Lab Pesticide Sci, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China 3.Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yu-Xiu,Wei, Deng-Guo,Zhu, Ye-Rong,et al. Synthesis, herbicidal activities, and 3D-QSAR of 2-cyanoacrylates containing aromatic methylamine moieties[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2008,56(1):204-212. |
| APA | Liu, Yu-Xiu.,Wei, Deng-Guo.,Zhu, Ye-Rong.,Liu, Shao-Hua.,Zhang, Yong-Lin.,...&Wang, Qing-Min.(2008).Synthesis, herbicidal activities, and 3D-QSAR of 2-cyanoacrylates containing aromatic methylamine moieties.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,56(1),204-212. |
| MLA | Liu, Yu-Xiu,et al."Synthesis, herbicidal activities, and 3D-QSAR of 2-cyanoacrylates containing aromatic methylamine moieties".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 56.1(2008):204-212. |
入库方式： OAI收割
来源：化学研究所
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