Interaction of spiro[(2R,3R,4S)-4-benzyloxy-2,3-iso-propylidenedioxy-1-oxacyclopentane-5,5 '-(2-nitromethylene-1,3-diazacyclohexane)] with bovine serum albumin
文献类型：期刊论文
| 作者 | Zhou, Qiuju1,2; Xiang, Junfeng1; Tang, Yalin1; Liao, Jiangpeng2,3; Yu, Chuyi; Du, Hongyan1,2; Yang, Qianfan1,2; Xu, Guangzhi1 |
| 刊名 | PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
 |
| 出版日期 | 2008-09-01 |
| 卷号 | 92期号:1页码:43-47 |
| 关键词 | 2-nitromethylene-1-3-diazacycloalkanes Bovine Serum Albumin Circular Dichroism Fluorescence Quenching |
| ISSN号 | 0048-3575 |
| DOI | 10.1016/j.pestbp.2008.06.002 |
| 英文摘要 | The interaction of a novel pesticide, NMD (spiro[(2R,3R,4S)-4-benzyloxy-2,3-iso-propylidenedioxy-1-oxacyclopentane-5,5'-(2-nitromethylene-1,3-diazacyclohexane)]), with bovine serum albumin (BSA) has been investigated by using absorption, fluorescence, and circular dichroism (CD) spectroscopy methods. Quenching of the fluorescence of BSA has been observed in the presence of NMD. The binding parameters were determined using Stern-Volmer equation. From the thermodynamic parameters calculated according to the van't Hoff equation, the enthalpy change Delta H, and entropy change AS were found to be -2.71 kJ mol(-1) and 82.56 J mol(-1) K-1, respectively. These values suggested that, apart from an initial hydrophobic association, the complex is held together by van der Waals interactions and hydrogen bonding. These results provided a quantitative understanding of the binding of NMD to BSA, which is important in understanding its toxicity in vertebrates. (C) 2008 Elsevier Inc. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000258560900008 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/65231]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Tang, Yalin |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Ctr Mol Sci,BNLMS, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Chem, Lab Mol Recognit & Select Synth, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Qiuju,Xiang, Junfeng,Tang, Yalin,et al. Interaction of spiro[(2R,3R,4S)-4-benzyloxy-2,3-iso-propylidenedioxy-1-oxacyclopentane-5,5 '-(2-nitromethylene-1,3-diazacyclohexane)] with bovine serum albumin[J]. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,2008,92(1):43-47. |
| APA | Zhou, Qiuju.,Xiang, Junfeng.,Tang, Yalin.,Liao, Jiangpeng.,Yu, Chuyi.,...&Xu, Guangzhi.(2008).Interaction of spiro[(2R,3R,4S)-4-benzyloxy-2,3-iso-propylidenedioxy-1-oxacyclopentane-5,5 '-(2-nitromethylene-1,3-diazacyclohexane)] with bovine serum albumin.PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,92(1),43-47. |
| MLA | Zhou, Qiuju,et al."Interaction of spiro[(2R,3R,4S)-4-benzyloxy-2,3-iso-propylidenedioxy-1-oxacyclopentane-5,5 '-(2-nitromethylene-1,3-diazacyclohexane)] with bovine serum albumin".PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 92.1(2008):43-47. |
入库方式： OAI收割
来源：化学研究所
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