pH-triggered reversible "stealth" polycationic micelles
文献类型：期刊论文
| 作者 | Gu, Jingxia1; Cheng, Woei-Ping2; Liu, Jiguang1; Lo, Sum-Yee2; Smith, David2; Qu, Xiaozhong1; Yang, Zhenzhong1
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| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2008 |
| 卷号 | 9期号:1页码:255-262 |
| ISSN号 | 1525-7797 |
| DOI | 10.1021/bm701084w |
| 英文摘要 | Amphiphilic polycations with a "stealth" cationic nature have been designed and synthesized by the PEGylation of polycationic amphiphile via a novel pH responsible benzoic imine linker. The linkage is stable in aqueous solution at physiological pH but cleaves in slight acidic conditions such as the extracellular environment of solid tumor and endosomes. The polymeric micelle formed from the amphiphilic "stealth" polycation contains a pH-switchable cationic surface driven by the reversible detachment/reattachment of the shielding PEG chains due to the cleavage/formation process of the imine linkage. At physiological pH, the micellar surface was shielded by the PEG corona, leading to lower cytotoxicity and less hemolysis, whereas in a mild acidic condition like in endosomes or solid tumors, the deshielding of the PEG chains exposed the positive charge on the micellar surface and retained the membrane disrupting ability. The amphiphilic "stealth" polycation is potentially useful as a drug targeting system toward tumors via endocytosis and trafficked through the endosomal pathway. |
| 语种 | 英语 |
| WOS记录号 | WOS:000252415600035 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/65265]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Qu, Xiaozhong |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lan Polymer Phys & Chem, Beijing 100080, Peoples R China 2.Robert Gordon Univ, Sch Pharm, Aberdeen AB10 1FR, Scotland |
| 推荐引用方式 GB/T 7714 | Gu, Jingxia,Cheng, Woei-Ping,Liu, Jiguang,et al. pH-triggered reversible "stealth" polycationic micelles[J]. BIOMACROMOLECULES,2008,9(1):255-262. |
| APA | Gu, Jingxia.,Cheng, Woei-Ping.,Liu, Jiguang.,Lo, Sum-Yee.,Smith, David.,...&Yang, Zhenzhong.(2008).pH-triggered reversible "stealth" polycationic micelles.BIOMACROMOLECULES,9(1),255-262. |
| MLA | Gu, Jingxia,et al."pH-triggered reversible "stealth" polycationic micelles".BIOMACROMOLECULES 9.1(2008):255-262. |
入库方式： OAI收割
来源：化学研究所
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