Self-assembly of a hydrophobic polypeptide containing a short hydrophilic middle segment: Vesicles to large compound micelles
文献类型：期刊论文
| 作者 | Sun, Jing1,2; Shi, Quan1,2; Chen, Xuesi1; Guo, Jinshan1,2; Jing, Xiabin1 |
| 刊名 | MACROMOLECULAR CHEMISTRY AND PHYSICS
 |
| 出版日期 | 2008-06-05 |
| 卷号 | 209期号:11页码:1129-1136 |
| 关键词 | Large Compound Micelles N-carboxyanhydride (Nca) Polypeptides Self-assembly Vesicles |
| ISSN号 | 1022-1352 |
| DOI | 10.1002/macp.200800018 |
| 英文摘要 | This report describes a facile route to prepare the vesicles and large compound micelles (LCMs) from a series of poly(epsilon-benzyloxycarbonyl L-lysine)-block-poly[diethylene glycol bis(3-amino propyl) ether]-block-poly(epsilon-benzyloxycarbonyl L-lySine) (PZLL-DGBE-PZLL) in their water solution, depending on molecular weight of the polypeptides. A pyrene probe is used to demonstrate the aggregate formation of PZLL-DGBE-PZLL in solution, and also to measure their critical micelle concentration as a function of molecular weight of the polymer. Transmission electron microscopy, atomic force microscopy, dynamic light scattering and confocal laser scanning microscopy are used to observe their aggregate morphologies. Rhodamine B is used as a fluorescent probe to confirm the structure of large compound micelles composed of many reverse micelles with aqueous cores. These polypeptides are prepared by ring-opening polymerization of a-amino acid N-carboxyanhydrides with a small molecule as the initiator. Their structures are confirmed by NMR and SEC-MALLS. These vesicles and large compound micelles are extremely expected to be used in drug delivery. |
| 语种 | 英语 |
| WOS记录号 | WOS:000256825900005 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/65563]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Jing,Shi, Quan,Chen, Xuesi,et al. Self-assembly of a hydrophobic polypeptide containing a short hydrophilic middle segment: Vesicles to large compound micelles[J]. MACROMOLECULAR CHEMISTRY AND PHYSICS,2008,209(11):1129-1136. |
| APA | Sun, Jing,Shi, Quan,Chen, Xuesi,Guo, Jinshan,&Jing, Xiabin.(2008).Self-assembly of a hydrophobic polypeptide containing a short hydrophilic middle segment: Vesicles to large compound micelles.MACROMOLECULAR CHEMISTRY AND PHYSICS,209(11),1129-1136. |
| MLA | Sun, Jing,et al."Self-assembly of a hydrophobic polypeptide containing a short hydrophilic middle segment: Vesicles to large compound micelles".MACROMOLECULAR CHEMISTRY AND PHYSICS 209.11(2008):1129-1136. |
入库方式： OAI收割
来源：化学研究所
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