Novel temperature- and pH-responsive graft copolymers composed of poly(L-glutamic acid) and poly(N-isopropylacrylamide)
文献类型：期刊论文
| 作者 | He, Chaoliang1; Zhao, Changwen1; Guo, Xinhua2; Guo, Zhaojun1; Chen, Xuesi1; Zhuang, Xiuli1; Liu, Shuying2; Jing, Xiabin1 |
| 刊名 | JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
 |
| 出版日期 | 2008-06-15 |
| 卷号 | 46期号:12页码:4140-4150 |
| 关键词 | Biodegradable Phase Behavior Poly(Glutamic Acid) Poly(N-isopropylacrylamide) Stimuli-sensitive Polymers |
| ISSN号 | 0887-624X |
| DOI | 10.1002/pola.22760 |
| 英文摘要 | A series of novel temperature- and pH-responsive graft copolymers, poly(L-glutamic acid)-g-poly(N-isopropylacrylamide), were synthesized by coupling amino-semitelechelic poly(N-isopropylacrylamide) with N-hydroxysuccinimide-activated poly(L-glutamic acid). The graft copolymers and their precursors were characterized, by ESI-FTICR Mass Spectrum, intrinsic viscosity measurements and proton nuclear magnetic resonance ((1)H NMR). The phase-transition and aggregation behaviors of the graft copolymers in aqueous solutions were investigated by the turbidity measurements and dynamic laser scattering. The solution behavior of the copolymers showed dependence on both temperature and pH. The cloud point (CP) of the copolymer solution at pH 5.0-7.4 was slightly higher than that of the solution of the PNIPAM homopolymer because of the hydrophilic nature of the poly(glutamic acid) (PGA) backbone. The CP markedly decreased when the pH was lowered from 5 to 4.2, caused by the decrease in hydrophilicity of the PGA backbone. At a temperature above the lower critical solution temperature of the PNIPAM chain, the copolymers formed amphiphilic core-shell aggregates at pH 4.5-7.4 and the particle size was reduced with decreasing pH. In contrast, larger hydrophobic aggregates were formed at pH 4.2. (C) 2008 Wiley Periodicals, Inc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000256643500026 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/65581]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Xuesi |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun Ctr Mass Spectrometry, Green Chem & Process Lab, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Chaoliang,Zhao, Changwen,Guo, Xinhua,et al. Novel temperature- and pH-responsive graft copolymers composed of poly(L-glutamic acid) and poly(N-isopropylacrylamide)[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2008,46(12):4140-4150. |
| APA | He, Chaoliang.,Zhao, Changwen.,Guo, Xinhua.,Guo, Zhaojun.,Chen, Xuesi.,...&Jing, Xiabin.(2008).Novel temperature- and pH-responsive graft copolymers composed of poly(L-glutamic acid) and poly(N-isopropylacrylamide).JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,46(12),4140-4150. |
| MLA | He, Chaoliang,et al."Novel temperature- and pH-responsive graft copolymers composed of poly(L-glutamic acid) and poly(N-isopropylacrylamide)".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 46.12(2008):4140-4150. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。