Noncovalently supported heterogeneous chiral amine catalysts for asymmetric direct aldol and Michael addition reactions
文献类型：期刊论文
| 作者 | Luo, Sanzhong1,2; Li, Jiuyuan1,2; Zhang, Long3,4; Xu, Hui1,2; Cheng, Jin-Pei3,4 |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2008 |
| 卷号 | 14期号:4页码:1273-1281 |
| 关键词 | Aldol Reaction Heterogeneous Catalysis Michael Addition Noncovalent Immobilization Organocatalysis |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.200701129 |
| 英文摘要 | A new strategy for the immobilization of asymmetric organocatalysts by combining polystyrene (PS)/sulfonic acids and chiral amines in situ through acid-base interactions is presented. The PS/sulfonic acids play a dual role as catalyst anchors and modulators for activity and stereoselectivity. Different types of polymeric sulfonic acids were examined and 1% divinylbenzene (DVB) cross-linked PS/sulfonic acid le with a medium loading of sulfonic acid moieties was found to be the optimal support. Furthermore, the noncovalency of this system allows combinatorial screening of optimal catalysts for the targeted reactions. In this regard, highly efficient and enantioselective heterogeneous catalysts were identified for the asymmetric direct aldol and Michael addition reactions. The catalysts could be easily recovered by filtration and reused for six cycles with similar stereoselectivity but slightly decreased activity. Significantly, the deactivated catalysts could be regenerated following an acidic washing/amine recharging procedure. |
| 语种 | 英语 |
| WOS记录号 | WOS:000252879800021 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/65737]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Luo, Sanzhong |
| 作者单位 | 1.Beijing Natl Lab Mol Sci, Ctr Chem Biol, Inst Chem, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China 3.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China 4.Nankai Univ, State Key Lab Coordinat Elementoorgan Chem, Tianjin 300071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Sanzhong,Li, Jiuyuan,Zhang, Long,et al. Noncovalently supported heterogeneous chiral amine catalysts for asymmetric direct aldol and Michael addition reactions[J]. CHEMISTRY-A EUROPEAN JOURNAL,2008,14(4):1273-1281. |
| APA | Luo, Sanzhong,Li, Jiuyuan,Zhang, Long,Xu, Hui,&Cheng, Jin-Pei.(2008).Noncovalently supported heterogeneous chiral amine catalysts for asymmetric direct aldol and Michael addition reactions.CHEMISTRY-A EUROPEAN JOURNAL,14(4),1273-1281. |
| MLA | Luo, Sanzhong,et al."Noncovalently supported heterogeneous chiral amine catalysts for asymmetric direct aldol and Michael addition reactions".CHEMISTRY-A EUROPEAN JOURNAL 14.4(2008):1273-1281. |
入库方式： OAI收割
来源：化学研究所
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