Crystallinity Control of Apatite Through Ca-EDTA Complexes and Porous Composites With PLGA
文献类型：期刊论文
| 作者 | Mochizuki, Chihiro1; Sasaki, Yuji1; Hara, Hiroki1; Sato, Mitsunobu1; Hayakawa, Tohru2; Yang, Fei3; Hu, Xixue3; Shen, Hong3; Wang, Shenguo3 |
| 刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
 |
| 出版日期 | 2009-07-01 |
| 卷号 | 90B期号:1页码:290-301 |
| 关键词 | Composite/hard Tissue Hydroxyl Apatite In Vitro Cell Adhesion |
| ISSN号 | 1552-4973 |
| DOI | 10.1002/jbm.b.31285 |
| 英文摘要 | Apatite compounds with different levels of crystallinity were prepared using Ca-EDTA complexes. Ca-deficient hydroxyapatite (CDHA) with low crystallinity was synthesized by ultrasonic stirring of a mixture of Ca-EDTA complex, phosphoric acid, and ammonium hydroxide in hydrogen peroxide aqueous solution. Mixtures of carbonate hydroxyapatite (HA) and CDHA with higher crystallinity were also prepared from a solution involving the same complex. The porous composites with lower or higher crystallinity apatite with a copolymer of poly(L-lactide-co-glycilide)(70/30) (PLGA(70/30)) were fabricated by a solution-casting/particles leaching method. The apatites and porous composites were characterized, and it was found that the degradation of composites of apatite with a low level of crystallinity was fastest in phosphate-bufferd saline (PBS) solution compared with other apatite composites with higher levels of crystallinity; however, the rate was smaller than that of PLGA alone. Plasma treatment influenced the degradation of composites in PBS and apatite precipitation in simulated body fluid (SBF). Hydroxyapatite deposition on the PLGA composite with the low crystallinity occurred six times faster than that on PLGA alone after immersion in SBF. The incorporation of apatite into the PLGA matrix did not cause any adverse effects on cell attachment in an assay employing human gingival fibroblasts. This study suggested that the current apatite and PLGA porous composite will be a promising scaffold material for tissue engineering. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 90B: 290-301, 2009 |
| 语种 | 英语 |
| WOS记录号 | WOS:000267298500034 |
| 出版者 | WILEY-LISS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/65835]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Mochizuki, Chihiro |
| 作者单位 | 1.Kogakuin Univ, Fac Engn, Coordinat Engn Lab, Tokyo 1920015, Japan 2.Nihon Univ, Sch Dent Matsudo, Dept Dent Biomat, Chiba 2718587, Japan 3.Chinese Acad Sci, Inst Chem, PPCL, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mochizuki, Chihiro,Sasaki, Yuji,Hara, Hiroki,et al. Crystallinity Control of Apatite Through Ca-EDTA Complexes and Porous Composites With PLGA[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2009,90B(1):290-301. |
| APA | Mochizuki, Chihiro.,Sasaki, Yuji.,Hara, Hiroki.,Sato, Mitsunobu.,Hayakawa, Tohru.,...&Wang, Shenguo.(2009).Crystallinity Control of Apatite Through Ca-EDTA Complexes and Porous Composites With PLGA.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,90B(1),290-301. |
| MLA | Mochizuki, Chihiro,et al."Crystallinity Control of Apatite Through Ca-EDTA Complexes and Porous Composites With PLGA".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 90B.1(2009):290-301. |
入库方式： OAI收割
来源：化学研究所
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