Clickable fluorophores for biological labeling-with or without copper
文献类型：期刊论文
| 作者 | Kele, Peter1,2; Li, Xiaohua2,3; Link, Martin2; Nagy, Krisztina1; Herner, Andras1; Lorincz, Krisztian1; Beni, Szabolcs4; Wolfbeis, Otto S.2 |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2009 |
| 卷号 | 7期号:17页码:3486-3490 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/b907741c |
| 英文摘要 | The synthesis of a set of new clickable fluorophores that virtually cover the whole visible spectrum reaching the near infra-red regime is presented herein. Besides dyes that are capable of participating in classical copper catalyzed 1,3-dipolar cycloaddition reactions with the counterparting function we have also prepared dyes containing a cyclooctyne moiety, an alkyne derivative that enables copper free clicking to azides. The suitability of these dyes for fluorescent labeling of biomolecules is presented by examples on model frameworks representing major biopolymer building blocks. The versatility of these dyes is presented in cell labeling experiments as well as by labeling the azide modified surface glycans of CHO-cells either by copper catalyzed or copper-free click reaction. These dyes are expected to have a large variety of applications in (bio)orthogonal labeling schemes both in vivo and in vitro. |
| 语种 | 英语 |
| WOS记录号 | WOS:000268975300019 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66105]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Kele, Peter |
| 作者单位 | 1.Eotvos Lorand Univ, Inst Chem, H-1117 Budapest, Hungary 2.Univ Regensburg, Inst Analyt Chem Chemo & Biosensors, D-93040 Regensburg, Germany 3.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 4.Semmelweis Univ, HAS Res Grp Drugs Abuse, Dept Pharmaceut Chem, H-1092 Budapest, Hungary |
| 推荐引用方式 GB/T 7714 | Kele, Peter,Li, Xiaohua,Link, Martin,et al. Clickable fluorophores for biological labeling-with or without copper[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2009,7(17):3486-3490. |
| APA | Kele, Peter.,Li, Xiaohua.,Link, Martin.,Nagy, Krisztina.,Herner, Andras.,...&Wolfbeis, Otto S..(2009).Clickable fluorophores for biological labeling-with or without copper.ORGANIC & BIOMOLECULAR CHEMISTRY,7(17),3486-3490. |
| MLA | Kele, Peter,et al."Clickable fluorophores for biological labeling-with or without copper".ORGANIC & BIOMOLECULAR CHEMISTRY 7.17(2009):3486-3490. |
入库方式： OAI收割
来源：化学研究所
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