CE-MS analysis of heroin and its basic impurities using a charged polymer-protected gold nanoparticle-coated capillary
文献类型：期刊论文
| 作者 | Zhang, Zhengxiang1; Yan, Bo1; Liu, Kelin2; Liao, Yiping1; Liu, Huwei1 |
| 刊名 | ELECTROPHORESIS
 |
| 出版日期 | 2009 |
| 卷号 | 30期号:2页码:379-387 |
| 关键词 | Ce-ms Gold Nanoparticles Heroin Illicit Drug Polymer |
| ISSN号 | 0173-0835 |
| DOI | 10.1002/elps.200800069 |
| 英文摘要 | The first application of charged polymer-protected gold nanoparticles (Au NPs) as semipermanent capillary coating in CE-MS was presented. Poly(diailyldimethylammonium chloride) (PDDA) was the only reducing and stabilizing agent for Au NPs preparation. Stable and repeatable coating with good tolerance to 0.1 M HCl, methanol, and ACN was obtained via a simple rinsing procedure. Au NPs enhanced the coating stability toward flushing by methanol, improved the run-to-run and capillary-to-capillary repeatabilities, and improved the separation efficiency of heroin and its basic impurities for tracing geographical origins of illicit samples. Baseline resolution of eight heroin-related alkaloids was achieved on the PDDA-protected Au NPs-coated capillary under the optimum conditions: 120 mM ammonium acetate (pH 5.2) with addition of 13% methanol, separation temperature 20 degrees C, applied voltage -20 kV, and capillary effective length 60.0 cm. CE-MS analysis with run-to-run RSDs (n = 5) of migration time in the range of 0.43-0.62% and RSDs (n = 5) of peak area in the range of 1.49-4.68% was obtained. The established CE-MS method would offer sensitive detection and confident identification of heroin and related compounds and provide an alternative to LC-MS and GC-MS for illicit drug control. |
| 语种 | 英语 |
| WOS记录号 | WOS:000263708900011 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66107]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Huwei |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Key Lab Bioorgan Chem & Mol Engn Minist Educ, Inst Analyt Chem,Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Inst Forens Sci, Minist Publ Secur, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhengxiang,Yan, Bo,Liu, Kelin,et al. CE-MS analysis of heroin and its basic impurities using a charged polymer-protected gold nanoparticle-coated capillary[J]. ELECTROPHORESIS,2009,30(2):379-387. |
| APA | Zhang, Zhengxiang,Yan, Bo,Liu, Kelin,Liao, Yiping,&Liu, Huwei.(2009).CE-MS analysis of heroin and its basic impurities using a charged polymer-protected gold nanoparticle-coated capillary.ELECTROPHORESIS,30(2),379-387. |
| MLA | Zhang, Zhengxiang,et al."CE-MS analysis of heroin and its basic impurities using a charged polymer-protected gold nanoparticle-coated capillary".ELECTROPHORESIS 30.2(2009):379-387. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。