The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol-block-(epsilon-caprolactone)] Copolymers
文献类型：期刊论文
| 作者 | Mao, Jing1,2; Gan, Zhihua1 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2009-11-10 |
| 卷号 | 9期号:11页码:1080-1089 |
| ISSN号 | 1616-5187 |
| 关键词 | Block Copolymers Controlled Polymerization Drug Delivery Enzymatic Degradation Micelles |
| DOI | 10.1002/mabi.200900104 |
| 英文摘要 | An amphiphilic diblock copolymer PG-b-PCL with well-controlled structure and pendant hydroxyl groups along hydrophilic block was synthesized by sequential anionic ring-opening polymerization. The micellization and drug release of PG-b-PCL copolymers using pyrene as a fluorescence probe were investigated for determining the influences of copolymer composition and lipase concentration on drug loading capacity and controlled release behavior. The biodegradation of PG-b-PCL copolymers was studied with microspheres as research samples. It has been concluded that the polar hydroxyl groups along each repeat unit of hydrophilic PG block in PG-b-PCL copolymer have great influences on drug encapsulation, drug release, and enzymatic degradation of micelles and microspheres. |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000271990000004 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66231]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Gan, Zhihua |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Engn Plast, Inst Chem, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao, Jing,Gan, Zhihua. The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol-block-(epsilon-caprolactone)] Copolymers[J]. MACROMOLECULAR BIOSCIENCE,2009,9(11):1080-1089. |
| APA | Mao, Jing,&Gan, Zhihua.(2009).The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol-block-(epsilon-caprolactone)] Copolymers.MACROMOLECULAR BIOSCIENCE,9(11),1080-1089. |
| MLA | Mao, Jing,et al."The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol-block-(epsilon-caprolactone)] Copolymers".MACROMOLECULAR BIOSCIENCE 9.11(2009):1080-1089. |
入库方式： OAI收割
来源：化学研究所
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