Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis
文献类型：期刊论文
| 作者 | Lu, Tiancheng1,2,3; Sun, Jing1,3; Chen, Xuexi1; Zhang, Peibiao1; Jing, Xiabin1 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2009-11-10 |
| 卷号 | 9期号:11页码:1059-1068 |
| 关键词 | Endocytosis Folic Acid Micelles Receptor Targeting |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.200900134 |
| 英文摘要 | A folate-conjugated copolymer PEG-PLA-PLL/folate was synthesized and mixed with pure PEG-PLA-PLL and a fluorescent model drug mFITC to prepare folate-conjugated micelles. The distribution of micelles was studied on cancer-cell-bearing mice via frozen slicing. The results show that mFITC is successfully encapsulated into folate(+) and folate(-)micelles; PEG-PLA-PLL micelles the latter can be internalized by both HeLa and CHO cells without selectivity due to their cationic surface charges, while folate(+)micelles exhibit more preferential endocytosis by HeLa cells than by CHO cells. The folate(-)micelles showed retention in both organs and tumors. The folate(+)micelles are a promising active targeting drug delivery system for FR over-expressing cells and they accumulate in tumor beds. |
| 语种 | 英语 |
| WOS记录号 | WOS:000271990000002 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66301]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Jilin Agr Univ, Sch Life Sci, Changchun 130118, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Tiancheng,Sun, Jing,Chen, Xuexi,et al. Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis[J]. MACROMOLECULAR BIOSCIENCE,2009,9(11):1059-1068. |
| APA | Lu, Tiancheng,Sun, Jing,Chen, Xuexi,Zhang, Peibiao,&Jing, Xiabin.(2009).Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis.MACROMOLECULAR BIOSCIENCE,9(11),1059-1068. |
| MLA | Lu, Tiancheng,et al."Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis".MACROMOLECULAR BIOSCIENCE 9.11(2009):1059-1068. |
入库方式： OAI收割
来源：化学研究所
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