Synthesis and biological evaluation of radioiodinated 2NUBTA as a cerebral ischemia marker
文献类型：期刊论文
| 作者 | Chu, Taiwei; Li, Zejun; Wang, Xiangyun |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2009-02-01 |
| 卷号 | 19期号:3页码:658-661 |
| 关键词 | Cerebral Ischemia Marker Radiolabeling Hypoxia Lipophilicity Intact Blood-brain Barrier 2-nitroimidazole Thioflaven-t |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2008.12.052 |
| 英文摘要 | N-[4-(Benzothiazol-2-yl) phenyl]-11-(2-nitroimidazole-1-yl) undecanamide (2NUBTA) was synthesized and radiolabeled with iodine-131. In vitro evaluation of the [(131)I] 2NUBTA using murine sarcoma S180 cells showed increase in radioactivity in hypoxic cells up to 4 h, while it was not in aerobic cells. Its potential as a cerebral ischemia marker was evaluated using gerbil stroke models that had been subjected to right common carotid artery ligation to produce cerebral ischemia. The uptake in the right cerebral hemisphere decreased slowly than that of the left and the right/left hemisphere uptake ratios increased with time going on. It indicated that [(131)I]2NUBTA might be a possible cerebral ischemia marker. (c) 2008 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000262707000016 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66311]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chu, Taiwei |
| 作者单位 | Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, BNLMS, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chu, Taiwei,Li, Zejun,Wang, Xiangyun. Synthesis and biological evaluation of radioiodinated 2NUBTA as a cerebral ischemia marker[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(3):658-661. |
| APA | Chu, Taiwei,Li, Zejun,&Wang, Xiangyun.(2009).Synthesis and biological evaluation of radioiodinated 2NUBTA as a cerebral ischemia marker.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(3),658-661. |
| MLA | Chu, Taiwei,et al."Synthesis and biological evaluation of radioiodinated 2NUBTA as a cerebral ischemia marker".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.3(2009):658-661. |
入库方式： OAI收割
来源：化学研究所
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