Desorption electrospray ionization mass spectrometry of DNA nucleobases: implications for a liquid film model
文献类型：期刊论文
| 作者 | Qiu, Bo; Luo, Hai |
| 刊名 | JOURNAL OF MASS SPECTROMETRY
 |
| 出版日期 | 2009-05-01 |
| 卷号 | 44期号:5页码:772-779 |
| 关键词 | Desorption Electrospray Ionization Ion Source Ionization Mechanism Nucleobases Clusters |
| ISSN号 | 1076-5174 |
| DOI | 10.1002/jms.1554 |
| 英文摘要 | Desorption electrospray ionization (DESI) mass spectrometry has been implemented on a commercial ion-trap mass spectrometer and used to optimize mass spectrometric conditions for DNA nucleobases: adenine, cytosine, thymine, and guanine. Experimental parameters including spray voltage, distance between mass spectrometer inlet and the sampled spot, and nebulizing gas inlet pressure were optimized. Cluster ions including some magic number clusters of nucleobases were observed for the first time using DESI mass spectrometry. The formation of the cluster species was found to vary with the nucleobases, acidification of the spray solvent, and the deposited sample amount. All the experimental results can be explained well using a liquid film model based on the two-step droplet pick-up mechanism. It is further suggested that solubility of the analytes in the spray solvent is an important factor to consider for their studies by using DESI. Copyright (C) 2009 John Wiley & Sons, Ltd. |
| 语种 | 英语 |
| WOS记录号 | WOS:000266681600019 |
| 出版者 | JOHN WILEY & SONS LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66323]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Luo, Hai |
| 作者单位 | Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, Bo,Luo, Hai. Desorption electrospray ionization mass spectrometry of DNA nucleobases: implications for a liquid film model[J]. JOURNAL OF MASS SPECTROMETRY,2009,44(5):772-779. |
| APA | Qiu, Bo,&Luo, Hai.(2009).Desorption electrospray ionization mass spectrometry of DNA nucleobases: implications for a liquid film model.JOURNAL OF MASS SPECTROMETRY,44(5),772-779. |
| MLA | Qiu, Bo,et al."Desorption electrospray ionization mass spectrometry of DNA nucleobases: implications for a liquid film model".JOURNAL OF MASS SPECTROMETRY 44.5(2009):772-779. |
入库方式： OAI收割
来源：化学研究所
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