A Novel Type of Dual-Modality Molecular Probe for MR and Nuclear Imaging of Tumor: Preparation, Characterization and in Vivo Application
文献类型：期刊论文
| 作者 | Liu, Shujie1; Jia, Bing2; Qiao, Ruirui1; Yang, Zhi4; Yu, Zilin2; Liu, Zhaofei2; Liu, Kan3; Shi, Jiyun2; Han Ouyang3; Wang, Fan2 |
| 刊名 | MOLECULAR PHARMACEUTICS
 |
| 出版日期 | 2009-07-01 |
| 卷号 | 6期号:4页码:1074-1082 |
| 关键词 | Dual-modality Molecular Probe Mri Nuclear Imaging Fe3o4 Nanocrystals Tumor |
| ISSN号 | 1543-8384 |
| DOI | 10.1021/mp900143a |
| 英文摘要 | A novel dual-modality molecular probe composed of biocompatible Fe3O4 nanocrystal, monoclonal antibody and radionuclide was designed and prepared. All functional components in the dual-modality molecular probe, i.e., Fe3O4, PEG, mAb 3H11 and 12 I-125, were chemically bonded together for forming a stable molecular probe. Systematic in vitro experiments were carried out for evaluating the biological activity of the antibody in the targeting probe. A series of in vivo experiments were performed based on the dual-modality imaging probe for detecting xenografted tumors in nude mice by MRI and gamma-imaging techniques. The pharmacokinetics of the dual-modality molecular probe in tumor-bearing nude mice was studied. |
| 语种 | 英语 |
| WOS记录号 | WOS:000268456300004 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66325]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Gao, Mingyuan |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 2.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China 3.Chinese Acad Med Sci, Canc Hosp, Beijing 100021, Peoples R China 4.Peking Univ, Oncol Sch, Beijing 100036, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Shujie,Jia, Bing,Qiao, Ruirui,et al. A Novel Type of Dual-Modality Molecular Probe for MR and Nuclear Imaging of Tumor: Preparation, Characterization and in Vivo Application[J]. MOLECULAR PHARMACEUTICS,2009,6(4):1074-1082. |
| APA | Liu, Shujie.,Jia, Bing.,Qiao, Ruirui.,Yang, Zhi.,Yu, Zilin.,...&Gao, Mingyuan.(2009).A Novel Type of Dual-Modality Molecular Probe for MR and Nuclear Imaging of Tumor: Preparation, Characterization and in Vivo Application.MOLECULAR PHARMACEUTICS,6(4),1074-1082. |
| MLA | Liu, Shujie,et al."A Novel Type of Dual-Modality Molecular Probe for MR and Nuclear Imaging of Tumor: Preparation, Characterization and in Vivo Application".MOLECULAR PHARMACEUTICS 6.4(2009):1074-1082. |
入库方式： OAI收割
来源：化学研究所
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