Gemini Surfactant-Induced DNA Condensation into a Beadlike Structure
文献类型：期刊论文
| 作者 | Wang, Xiao-Ling1; Zhang, Xing-Hua1; Cao, Meiwen2; Zheng, Hai-Zi1; Xiao, Bin1; Wang, Yilin2; Li, Ming1 |
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY B
 |
| 出版日期 | 2009-02-26 |
| 卷号 | 113期号:8页码:2328-2332 |
| ISSN号 | 1520-6106 |
| DOI | 10.1021/jp8078887 |
| 英文摘要 | Using a magnetic tweezers (MT) apparatus and an atomic force microscope (AFM), we studied the condensation of DNA induced by the cationic gemini surfactant hexyl-alpha,omega-bisdodecyidimethylammonium bromide (C(12)C(6)C(12)Br(2)). Stepwise condensation events were found for forces from 0.5 to 4 pN, with a decrease in DNA extension by similar to 100 nm in each condensation event. Applied stretching forces larger than 6 pN were found to be able to decondense the condensates in a similar intermittent stepwise manner, but with similar to 60 nm of DNA released in each decondensation event. These observations are consistent with AFM images that show beadlike structures on DNA. The results lead to a model in which, during condensation, independent beadlike structures are initially formed on DNA, and as the local density of the beads increases, they compact into higher-order structures while maintaining their independence. The condensation process is different from any previously reported condensation process, but it is somewhat similar to that of chromatin assembly. |
| 语种 | 英语 |
| WOS记录号 | WOS:000263529500014 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66413]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Ming |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Condensed Matter Phys, Inst Phys, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Key Lab Colloid & Interface Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiao-Ling,Zhang, Xing-Hua,Cao, Meiwen,et al. Gemini Surfactant-Induced DNA Condensation into a Beadlike Structure[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2009,113(8):2328-2332. |
| APA | Wang, Xiao-Ling.,Zhang, Xing-Hua.,Cao, Meiwen.,Zheng, Hai-Zi.,Xiao, Bin.,...&Li, Ming.(2009).Gemini Surfactant-Induced DNA Condensation into a Beadlike Structure.JOURNAL OF PHYSICAL CHEMISTRY B,113(8),2328-2332. |
| MLA | Wang, Xiao-Ling,et al."Gemini Surfactant-Induced DNA Condensation into a Beadlike Structure".JOURNAL OF PHYSICAL CHEMISTRY B 113.8(2009):2328-2332. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。