Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate)
文献类型：期刊论文
| 作者 | Hu, Xiuli1,2; Chen, Xuesi1; Wei, Jizheng1,2; Liu, Shi1; Jing, Xiabin1 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2009-05-13 |
| 卷号 | 9期号:5页码:456-463 |
| 关键词 | Biodegradable Core Crosslinking Drug Delivery Systems Polycarbonates Self-assembly |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.200800158 |
| 英文摘要 | A biodegradable amphiphilic block copolymer, PEG-b-P(LA-co-MAC), was used to prepare spherical micelles consisting of a hydrophobic P(LA-co-MAC) core and a hydrophilic PEG shell. To improve their stability, the micelles were crosslinked by radical polymerization of the double bonds in the hydrophobic blocks. The crosslinked micelles had similar sizes and a narrow size distribution compared to their uncrosslinked precursor. The improved stability of the crosslinked micelles was confirmed by measurements of the CMC and a thermodynamic investigation. These micelles can internalize into Hela cells in vitro as demonstrated by inverted fluorescence microscopy and CLSM. These stabilized nanoscale micelles have potential use in biomedical applications such as drug delivery and disease diagnosis. |
| 语种 | 英语 |
| WOS记录号 | WOS:000266456200007 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66449]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xiuli,Chen, Xuesi,Wei, Jizheng,et al. Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate)[J]. MACROMOLECULAR BIOSCIENCE,2009,9(5):456-463. |
| APA | Hu, Xiuli,Chen, Xuesi,Wei, Jizheng,Liu, Shi,&Jing, Xiabin.(2009).Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate).MACROMOLECULAR BIOSCIENCE,9(5),456-463. |
| MLA | Hu, Xiuli,et al."Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate)".MACROMOLECULAR BIOSCIENCE 9.5(2009):456-463. |
入库方式： OAI收割
来源：化学研究所
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