Electrospinning of multicomponent ultrathin fibrous nonwovens for semi-occlusive wound dressings
文献类型：期刊论文
| 作者 | Hong, Youliang1; Li, Yanan2; Zhuang, Xiuli1; Chen, Xuesi1; Jing, Xiabin1 |
| 刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
 |
| 出版日期 | 2009-05-01 |
| 卷号 | 89A期号:2页码:345-354 |
| 关键词 | Electrospinning Multicomponent Ultrathin Fibers Antibacterial Ointment-releasing Nonwoven Semi-occlusive Wound Dressing |
| ISSN号 | 1549-3296 |
| DOI | 10.1002/jbm.a.31968 |
| 英文摘要 | This work describes the design and assembly of multifunctional and cost-efficient composite fiber nonwovens as semi-occlusive wound dressings using a simple electrospinning process to incorporate a variety Of functional components into an Ultrathin fiber. These components include non-hydrophilic poly(L-lactide) (PLLA) as fibrous backbone, hydrophilic poly(vinyl pyrrolidone)iodine (PVP-I), TiO(2) nanoparticles, zinc chloride as antimicrobial, odor-controlling, and antiphlogistic agents, respectively. The process of synthesis starts with a multicomponent solution Of PLLA, PVP, TiO(2) nanoparticles plus zinc chloride, in which TiO(2) nanoparticles are synthesized by in situ hydrolysis of TiO(2) precursors in a PVP Solution for the sake of obtaining the particle-uniformly dispersive solution. Subsequent electrospinning generates the corresponding composite fibers. A further iodine vapor treatment to the composite fibers combines iodine with PVP to produce the PVP-I complexes. Experiments indicate that the assembled composite fibers (300-400 nm) possess the ointment-releasing characteristic and the phase-separate, core-sheath structures in which PVP-I residing in fiber Surface layer becomes the sheath, and PLLA distributing inside the fiber acts as the core. Based on this design, the structural advantages combining active components endow the assembled composite nonwovens with a variety of functions, especially, the existence of PVP-I, endows the nonwoven with water absorbability, antimicrobial activity, adhesive ability, and transformable characteristic from hydrophilicity to non-hydrophilicity. The multifunctional, cost-efficient, and ointment-releasing characteristics make the multicomponent composite fibrous nonwovens potentially useful in applications such as initial stage of dressing of the cankerous or contaminated wounds. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 89A: 345-354, 2009 |
| 语种 | 英语 |
| WOS记录号 | WOS:000264850200007 |
| 出版者 | WILEY-LISS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66485]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Xuesi |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Jilin Univ, Hosp 1, Dept Pharm, Changchun 130012, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hong, Youliang,Li, Yanan,Zhuang, Xiuli,et al. Electrospinning of multicomponent ultrathin fibrous nonwovens for semi-occlusive wound dressings[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2009,89A(2):345-354. |
| APA | Hong, Youliang,Li, Yanan,Zhuang, Xiuli,Chen, Xuesi,&Jing, Xiabin.(2009).Electrospinning of multicomponent ultrathin fibrous nonwovens for semi-occlusive wound dressings.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,89A(2),345-354. |
| MLA | Hong, Youliang,et al."Electrospinning of multicomponent ultrathin fibrous nonwovens for semi-occlusive wound dressings".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 89A.2(2009):345-354. |
入库方式： OAI收割
来源：化学研究所
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