Preparation, Surface Properties and Biological Activity of the Composite of Poly (lactide-co-glycolide) and Bioglass Nanoparticles Surface Grafted with Poly(L-lactide)
文献类型：期刊论文
| 作者 | Dong Shu-Jun1,2; Yu Ting2; Wei Jun-Chao2; Jing Xia-Bin2; Zhou Yan-Min1; Zhang Pei-Biao2; Chen Xue-Si2 |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2009-05-10 |
| 卷号 | 30期号:5页码:1018-1023 |
| 关键词 | Bioglass Nanoparticle Surface Grafting Poly(Lactide-co-glycolide) (Plga) Nanocomposite Bioactivity |
| ISSN号 | 0251-0790 |
| 英文摘要 | SiO(2)-CaO-P(2)O(5) gel bioglass (BG) nanoparticles with the diameter of 40 nm were synthesized by sol-gel approach. The surface of BG nanoparticles was grafted through the ring-open polymerization of the L-lactide to yield poly (L-lactide) (PLLA) grafted gel particle (PLLA-g-BG). The PLLA-g-BG was further blended with poly(lactide-co-glycolide) (PLGA) to prepare the nanocomposites of PLLA-g-BG/PLGA with the various blend ratios of two phases. PLLA-g-BG accounted 10%, 20% and 40% in the composite, respectively. TGA, ESEM and EDX were used to analyze the graft ratio of PLLA-g-BG, the dispersion of nano-particles and the surface elements of the composites respectively. The rabbit osteoblasts were seeded and cultured on the thin films of composites in vitro. The cell adhesion, spreading and growth of osteoblasts were analyzed with FITC staining, NIH Image J software and MTT assay. The change of cell cycle was monitored by flow cytometry (FCM). The results demonstrated that the Surface modification of BG with PLLA could significantly improve the dispersing of the particles in the matrix of PLGA. The nanocomposite with 20% PLLA-g-BG exhibited superior surface properties, including roughness and plenty of silicon, calcium and phosper, to enhance the adhesion, spreading and proliferation of osteoblasts. Our results indicate that the application of PLLA-g-BG with a certain blend ratio can improve the bioactivity and biocompatibility of biodegradable polyester. |
| 语种 | 英语 |
| WOS记录号 | WOS:000266417200035 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66525]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang Pei-Biao |
| 作者单位 | 1.Jilin Univ, Stomatol Sch, Changchun 130041, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong Shu-Jun,Yu Ting,Wei Jun-Chao,et al. Preparation, Surface Properties and Biological Activity of the Composite of Poly (lactide-co-glycolide) and Bioglass Nanoparticles Surface Grafted with Poly(L-lactide)[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2009,30(5):1018-1023. |
| APA | Dong Shu-Jun.,Yu Ting.,Wei Jun-Chao.,Jing Xia-Bin.,Zhou Yan-Min.,...&Chen Xue-Si.(2009).Preparation, Surface Properties and Biological Activity of the Composite of Poly (lactide-co-glycolide) and Bioglass Nanoparticles Surface Grafted with Poly(L-lactide).CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,30(5),1018-1023. |
| MLA | Dong Shu-Jun,et al."Preparation, Surface Properties and Biological Activity of the Composite of Poly (lactide-co-glycolide) and Bioglass Nanoparticles Surface Grafted with Poly(L-lactide)".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 30.5(2009):1018-1023. |
入库方式： OAI收割
来源：化学研究所
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