Comparative study of paclitaxel physically encapsulated in and chemically conjugated with PEG-PLA
文献类型：期刊论文
| 作者 | Xu, Xiaoyi1; Zhang, Xuefei2; Wang, Xiuhong1; Li, Yuxin1; Jing, Xiabin3 |
| 刊名 | POLYMERS FOR ADVANCED TECHNOLOGIES
 |
| 出版日期 | 2009-11-01 |
| 卷号 | 20期号:11页码:843-848 |
| 关键词 | Antitumor Activity Conjugate Controlled Release Micelle Paclitaxel |
| ISSN号 | 1042-7147 |
| DOI | 10.1002/pat.1341 |
| 英文摘要 | Paclitaxel-loaded poly(ethylene glycol)-b-poly(L-lactide (LA)) (PEG-PLA) micelles were prepared by two methods. One is physical encapsulation of paclitaxel in micelles composed of a PEG-PLA block copolymer and the other is based on a PEG-PLA-paclitaxel conjugate, abbreviated as "conjugate micelles" Their physicochemical characteristics, e.g. critical micelle concentration (CMC), morphology, and micelle size distribution were then evaluated by means of fluorescence spectroscopy, scanning electron microscopy (SEM), and dynamic light scattering (DLS). The results show that the CMC of PEG-PLA-paclitaxel and PEG-PLA are 6.31 x 10(4) and 1.78 x 10(-3) g L-1, respectively. Both micelles assume a spherical shape with comparable diameters and have unimodal size distribution. Moreover, in vitro drug delivery behavior was studied by high performance liquid chromatography (HPLC). The antitumor activity of the paclitaxel-loaded micelles against human liver cancer H7402 cells was evaluated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method. The conjugate micelles show a lower burst release during the initial stage and higher accumulative release amount of paclitaxel after a period of time while the encapsulated ones behave in the opposite way. Both the paclitaxel-loaded micelles showed comparable anticancer efficacy with the free drug. Copyright (C) 2008 John Wiley & Sons, Ltd. |
| 语种 | 英语 |
| WOS记录号 | WOS:000271051900005 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66589]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Yuxin |
| 作者单位 | 1.NE Normal Univ, Res Ctr Agr & Med Gene Engn, Minist Educ, Inst Cytol & Genet, Changchun 130024, Jilin, Peoples R China 2.Xiangtan Univ, Coll Chem, Xiangtan 411105, Hunan, Peoples R China 3.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Xiaoyi,Zhang, Xuefei,Wang, Xiuhong,et al. Comparative study of paclitaxel physically encapsulated in and chemically conjugated with PEG-PLA[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2009,20(11):843-848. |
| APA | Xu, Xiaoyi,Zhang, Xuefei,Wang, Xiuhong,Li, Yuxin,&Jing, Xiabin.(2009).Comparative study of paclitaxel physically encapsulated in and chemically conjugated with PEG-PLA.POLYMERS FOR ADVANCED TECHNOLOGIES,20(11),843-848. |
| MLA | Xu, Xiaoyi,et al."Comparative study of paclitaxel physically encapsulated in and chemically conjugated with PEG-PLA".POLYMERS FOR ADVANCED TECHNOLOGIES 20.11(2009):843-848. |
入库方式： OAI收割
来源：化学研究所
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