Synthesis of Amphiphilic Biodegradable Glycocopolymers Based on Poly(epsilon-caprolactone) by Ring-Opening Polymerization and Click Chemistry
文献类型：期刊论文
| 作者 | Xu, Ning; Wang, Rui; Du, Fu-Sheng; Li, Zi-Chen |
| 刊名 | JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
 |
| 出版日期 | 2009-07-15 |
| 卷号 | 47期号:14页码:3583-3594 |
| 关键词 | Amphiphilic Biodegradable Block Copolymers "click" Chemistry Glycopolymer Polyesters |
| ISSN号 | 0887-624X |
| DOI | 10.1002/pola.23443 |
| 英文摘要 | Amphiphilic, biodegradable block glycopolymers based oil poly(epsilon-caprolactone) (PCL) with various pendent saccharides were synthesized by combination of ring-opening polymerization (ROP) and "click" chemistry. PCL macroinitiators obtained by ROP of epsilon-caprolactone were used to initiate the ROP of 2-bromo-epsilon-caprolactone (BrCL) to get diblock copolymers, PCL-b-PBrCL. Reaction of the block copolymers with sodium azide converted the bromine groups in the PBrCL block to azide groups. In the final step, click chemistry of alkynyl saccharides with the pendent azide groups of PCL-b-PBrCL led to the formation of the amphiphilic block glycopolymers. These copolymers were characterized by (1)H NMR spectroscopy and gel permeation chromatography. The self-assembly behavior of the amphiphilic block copolymers was investigated using transmission electron microscopy and atomic force microscope, spherical aggregates with saccharide groups on the surface were observed, and the aggregates could bind reversibly with Concanavalin A. (C) 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 3583-3594, 2009 |
| 语种 | 英语 |
| WOS记录号 | WOS:000267444200010 |
| 出版者 | JOHN WILEY & SONS INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66601]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Zi-Chen |
| 作者单位 | Peking Univ, Coll Chem & Mol Engn, BNLMS,Minist Educ, Key Lab Polymer Chem & Phys, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Ning,Wang, Rui,Du, Fu-Sheng,et al. Synthesis of Amphiphilic Biodegradable Glycocopolymers Based on Poly(epsilon-caprolactone) by Ring-Opening Polymerization and Click Chemistry[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2009,47(14):3583-3594. |
| APA | Xu, Ning,Wang, Rui,Du, Fu-Sheng,&Li, Zi-Chen.(2009).Synthesis of Amphiphilic Biodegradable Glycocopolymers Based on Poly(epsilon-caprolactone) by Ring-Opening Polymerization and Click Chemistry.JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,47(14),3583-3594. |
| MLA | Xu, Ning,et al."Synthesis of Amphiphilic Biodegradable Glycocopolymers Based on Poly(epsilon-caprolactone) by Ring-Opening Polymerization and Click Chemistry".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 47.14(2009):3583-3594. |
入库方式： OAI收割
来源：化学研究所
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