Facile Preparation of a New Gadofullerene-Based Magnetic Resonance Imaging Contrast Agent with High H-1 Relaxivity
文献类型：期刊论文
| 作者 | Shu, Chunying3; Corwin, Frank D.1; Zhang, Jianfei3; Chen, Zhijian2; Reid, Jonathan E.3; Sun, Minghao1; Xu, Wei4; Sim, Jae Hyun3; Wang, Chunru4; Fatouros, Panos P.1 |
| 刊名 | BIOCONJUGATE CHEMISTRY
 |
| 出版日期 | 2009-06-01 |
| 卷号 | 20期号:6页码:1186-1193 |
| ISSN号 | 1043-1802 |
| DOI | 10.1021/bc900051d |
| 英文摘要 | A new magnetic resonance imaging (MRI) contrast agent based on the trimetallic nitride templated (TNT) metallofullerene Gd3N@C-80 was synthesized by a facile method in high yield. The observed longitudinal and transverse relaxivities r(1) and r(2) for water hydrogens in the presence of the water-soluble gadofullerene 2 Gd3N@C-80(OH)(similar to 26)(CH2CH2COOM)(similar to 16) (M = Na or H) are 207 and 282 mM(-1) s(-1) (per C-80 cage) at 2.4 T, respectively; these values are 50 times larger than those of Gd3+ poly(aminocarboxylate) complexes, such as commercial Omniscan and Magnevist. This high H-1 relaxivity for this new hydroxylated and carboxylated gadofullerene derivative provides high signal enhancement at significantly lower Gd concentration as demonstrated by in vitro and in vivo MRI studies. Dynamic light scattering data reveal a unimodal size distribution with an average hydrodynamic radius of ca. 78 nm in pure water (pH = 7), which is significantly different from other hydroxylated or carboxylated. fullerene and metallofullerene derivatives reported to date. Agarose gel infusion results indicate that the gadofullerene 2 displayed diffusion properties different from those of commercial Omniscan and those of PEG5000 modified Gd3N@C-80. The reactive carboxyl functionality present on this highly efficient contrast agent may also serve as a precursor for biomarker tissue-targeting purposes. |
| 语种 | 英语 |
| WOS记录号 | WOS:000267117600013 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66639]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Fatouros, Panos P. |
| 作者单位 | 1.Virginia Commonwealth Univ, Dept Radiol, Richmond, VA 23298 USA 2.Virginia Commonwealth Univ, Dept Neurosurg, Richmond, VA 23298 USA 3.Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA 4.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shu, Chunying,Corwin, Frank D.,Zhang, Jianfei,et al. Facile Preparation of a New Gadofullerene-Based Magnetic Resonance Imaging Contrast Agent with High H-1 Relaxivity[J]. BIOCONJUGATE CHEMISTRY,2009,20(6):1186-1193. |
| APA | Shu, Chunying.,Corwin, Frank D..,Zhang, Jianfei.,Chen, Zhijian.,Reid, Jonathan E..,...&Dorn, Harry C..(2009).Facile Preparation of a New Gadofullerene-Based Magnetic Resonance Imaging Contrast Agent with High H-1 Relaxivity.BIOCONJUGATE CHEMISTRY,20(6),1186-1193. |
| MLA | Shu, Chunying,et al."Facile Preparation of a New Gadofullerene-Based Magnetic Resonance Imaging Contrast Agent with High H-1 Relaxivity".BIOCONJUGATE CHEMISTRY 20.6(2009):1186-1193. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。