Poly(alpha,L-glutamic acid) Microspheres for Oral Insulin Delivery
文献类型：期刊论文
| 作者 | Han Ya-Dong1,2; Xia Jia-Liang1,2; He Pan1,2; Tian Hua-Yu1; Chen Xue-Si1; Jing Xia-Bin1 |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2009-12-10 |
| 卷号 | 30期号:12页码:2521-2524 |
| ISSN号 | 0251-0790 |
| 关键词 | Microsphere Oral Insulin Delivery Anhydrous Emulsion Ph-sensitive Drug Release Poly(Alpha L-glutamic Acid) |
| 英文摘要 | Insulin-loaded poly(alpha,L-glutamic acid) microspheres for oral delivery were prepared by anhydrous emulsion system. The microspheres had diameters of 5-20 mu m, and drug loading of 5%-9%. The microspheres had good pH sensitive release behavior. In gastric simulated fluid about 5% of insulin was released from microspheres after 2 h, while in intestinal simulated fluid over 90% of insulin released. The effect of polymer molecular weight, theoretical drug loading and polymer solution concentration to the microsphere release profile were investigated. |
| 语种 | 英语 |
| 出版者 | HIGHER EDUCATION PRESS |
| WOS记录号 | WOS:000273792900039 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66719]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen Xue-Si |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han Ya-Dong,Xia Jia-Liang,He Pan,et al. Poly(alpha,L-glutamic acid) Microspheres for Oral Insulin Delivery[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2009,30(12):2521-2524. |
| APA | Han Ya-Dong,Xia Jia-Liang,He Pan,Tian Hua-Yu,Chen Xue-Si,&Jing Xia-Bin.(2009).Poly(alpha,L-glutamic acid) Microspheres for Oral Insulin Delivery.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,30(12),2521-2524. |
| MLA | Han Ya-Dong,et al."Poly(alpha,L-glutamic acid) Microspheres for Oral Insulin Delivery".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 30.12(2009):2521-2524. |
入库方式： OAI收割
来源：化学研究所
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