Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization
文献类型：期刊论文
| 作者 | Zhang, Wei1; Jiang, Yaxin1; Wang, Qiang2; Ma, Xinyong1; Xiao, Zeyu1; Zuo, Wei2; Fang, Xiaohong1; Chen, Guang2 |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2009-09-15 |
| 卷号 | 106期号:37页码:15679-15683 |
| 关键词 | Serine/threonine Kinase Receptor Subunit Stoichiometry |
| ISSN号 | 0027-8424 |
| DOI | 10.1073/pnas.0908279106 |
| 英文摘要 | Transforming growth factor-beta (TGF-beta) elicits its signals through two transmembrane serine/threonine kinase receptors, type II (T beta RII) and type I receptors. It is generally believed that the initial receptor dimerization is an essential event for receptor activation. However, previous studies suggested that TGF-beta signals by binding to the preexisting T beta RII homodimer. Here, using single molecule microscopy to image green fluorescent protein (GFP)-labeled T beta RII on the living cell surface, we demonstrated that the receptor could exist as monomers at the low expression level in resting cells and dimerize upon TGF-beta stimulation. This work reveals a model in which the activation of serine-threonine kinase receptors is also accomplished via dimerization of monomers, suggesting that receptor dimerization is a general mechanism for ligand-induced receptor activation. |
| 语种 | 英语 |
| WOS记录号 | WOS:000269806600033 |
| 出版者 | NATL ACAD SCIENCES |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/66861]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Fang, Xiaohong |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Mol Nanostruct & Nanotechnol, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Tsinghua Univ, Dept Biol Sci & Biotechnol, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Wei,Jiang, Yaxin,Wang, Qiang,et al. Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2009,106(37):15679-15683. |
| APA | Zhang, Wei.,Jiang, Yaxin.,Wang, Qiang.,Ma, Xinyong.,Xiao, Zeyu.,...&Chen, Guang.(2009).Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,106(37),15679-15683. |
| MLA | Zhang, Wei,et al."Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106.37(2009):15679-15683. |
入库方式： OAI收割
来源：化学研究所
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