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6-Membered ring intermediates in polymerization of N-carboxyanhydride-L-alpha-arginine in H2O

文献类型：期刊论文

作者Xin Liang1; Ren Jie1; Xiang JunFeng2; Yan Qin1; Xie Yi1; Wang KongJiang1; Lai PingAn3; Bai YaDuo3
刊名SCIENCE IN CHINA SERIES B-CHEMISTRY
出版日期2009-08-01
卷号52期号:8页码:1220-1226
关键词N-carboxyanhydride L-arg-nca Intermediates L-alpha-arginine Polymerization
ISSN号1006-9291
DOI10.1007/s11426-009-0112-1
英文摘要In polymerization of N-carboxyanhydride-L-alpha-arginine (L-Arg-NCA) in H2O, nucleophilic reaction of guanidine group with the carbonyl group of L-Arg-NCA leads to quick intramolecular rearrangement, yielding a 6-membered ring intermediate 1-amidino-3-amino-2-piperidone, which is either elongated by another L-Arg-NCA yielding arginyl-1-amidino-3-amino-2-piperidone or hydrolyzed to L-alpha-arginine. The oligoarginines are formed mainly through hydrolysis of arginyl-1-amidino-3-amino-2-piperidones. This is a unique pathway in polymerization of L-Arg-NCA with regard to the usual pathway of elongations by reaction of N-carboxyanhydride-L-alpha-amino acid with L-alpha-amino acid or oligopeptides.
语种英语
WOS记录号WOS:000268514800022
出版者SCIENCE PRESS
源URL[http://ir.iccas.ac.cn/handle/121111/66975]  
专题中国科学院化学研究所
通讯作者Xiang JunFeng
作者单位1.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, BNLMS, Beijing 100080, Peoples R China
3.Beijing Entry Exit Inspect & Quarantine, Beijing 100026, Peoples R China
推荐引用方式
GB/T 7714		 Xin Liang,Ren Jie,Xiang JunFeng,et al. 6-Membered ring intermediates in polymerization of N-carboxyanhydride-L-alpha-arginine in H2O[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2009,52(8):1220-1226.
APA Xin Liang.,Ren Jie.,Xiang JunFeng.,Yan Qin.,Xie Yi.,...&Bai YaDuo.(2009).6-Membered ring intermediates in polymerization of N-carboxyanhydride-L-alpha-arginine in H2O.SCIENCE IN CHINA SERIES B-CHEMISTRY,52(8),1220-1226.
MLA Xin Liang,et al."6-Membered ring intermediates in polymerization of N-carboxyanhydride-L-alpha-arginine in H2O".SCIENCE IN CHINA SERIES B-CHEMISTRY 52.8(2009):1220-1226.

入库方式： OAI收割

来源：化学研究所

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