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Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells

文献类型：期刊论文

作者Chu, Taiwei1; Xu, Hong1; Yang, Zhi2,3; Wang, Xiangyun1
刊名APPLIED RADIATION AND ISOTOPES
出版日期2009-04-01
卷号67期号:4页码:590-593
关键词(99m)Tc Complex Hypoxia Marker Lipophilicity Hydroxamamide Labeling
ISSN号0969-8043
DOI10.1016/j.apradiso.2008.12.003
英文摘要Three new hydroxamamide derivatives with different lipophilicity, N'-hydroxy-N-methyl-3-(4-nitro-1H-imidazol-1-yl)propanamidine, N-butyl-N'-hydroxy-3-(4-nitro-1H-imidazol-1-yl)propanamidine, and N'-hydroxy-3-(4-nitro-1H-imidazol-1-yl)-N-octadecyl propanamidine were easily synthesized and labeled with technetium-99m as markers for hypoxic cells. The results of in vitro experiment indicate that the accumulation of three (99m)Tc-complexes steadily increases with time in hypoxic cells, but fluctuates with time and has no fixed trend in aerobic cells; the complex with higher lipophilicity shows more uptake in cells; and the effect of lipophilicity of the (99m)Tc-complexes on the hypoxic/aerobic difference can be neglected. (C) 2009 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000264305500017
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://ir.iccas.ac.cn/handle/121111/67027]  
专题中国科学院化学研究所
通讯作者Chu, Taiwei
作者单位1.Peking Univ, BNLMS, Dept Appl Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Peking Univ, Sch Oncol, Beijing 100036, Peoples R China
3.Peking Univ, Beijing Inst Canc Res, Beijing 100036, Peoples R China
推荐引用方式
GB/T 7714		 Chu, Taiwei,Xu, Hong,Yang, Zhi,et al. Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells[J]. APPLIED RADIATION AND ISOTOPES,2009,67(4):590-593.
APA Chu, Taiwei,Xu, Hong,Yang, Zhi,&Wang, Xiangyun.(2009).Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells.APPLIED RADIATION AND ISOTOPES,67(4),590-593.
MLA Chu, Taiwei,et al."Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells".APPLIED RADIATION AND ISOTOPES 67.4(2009):590-593.

入库方式： OAI收割

来源：化学研究所

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