Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex
文献类型：期刊论文
| 作者 | Wang, Fuyi1,3; Habtemariam, Abraha2,3; van der Geer, Erwin P. L.3; Deeth, Robert J.2; Gould, Robert3; Parsons, Simon3; Sadler, Peter J.2,3 |
| 刊名 | JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
 |
| 出版日期 | 2009-09-01 |
| 卷号 | 14期号:7页码:1065-1076 |
| 关键词 | Organometallic Ruthenium Thiocyanate Ligand Anticancer Agents Gmp |
| ISSN号 | 0949-8257 |
| DOI | 10.1007/s00775-009-0549-x |
| 英文摘要 | The organoruthenium complex [(eta(6)-hmb)Ru(en)(Cl)][PF(6)] (hmb is hexamethylbenzene, en is ethylenediamine) undergoes facile aquation and then reacts with KSCN in unbuffered solution to give the S-coordinated thiocyanato product [(eta(6)-hmb)Ru(en)(S-SCN)](+) which slowly converts to the thermodynamically favored N-bound complex [(eta(6)-hmb)Ru(en)(N-NCS)](+) (1 (+)). Complex 1 was synthesized and characterized by X-ray crystallography and mass spectrometry. Despite its lack of hydrolysis over 24 h, complex 1 exhibits moderate cytotoxicity (IC(50) 24 mu M) towards the human ovarian cancer cell line A2780, comparable with that of the chlorido analogue which is thought to be activated (towards potential target DNA) via a rapid aquation (Wang et. al. in Proc Natl Acad Sci USA 102:18269-18274, 2005). Detailed kinetic studies suggest that complex 1 binds to guanosine 5'-monophosphate (GMP) through direct N7 substitution of the N-bound SCN ligand. In the presence of a high concentration of chloride (104 mM), however, complex 1 may bind partly to GMP via Cl substitution. |
| 语种 | 英语 |
| WOS记录号 | WOS:000269912600007 |
| 出版者 | SPRINGER |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67127]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Fuyi |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England 3.Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland |
| 推荐引用方式 GB/T 7714 | Wang, Fuyi,Habtemariam, Abraha,van der Geer, Erwin P. L.,et al. Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,2009,14(7):1065-1076. |
| APA | Wang, Fuyi.,Habtemariam, Abraha.,van der Geer, Erwin P. L..,Deeth, Robert J..,Gould, Robert.,...&Sadler, Peter J..(2009).Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex.JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,14(7),1065-1076. |
| MLA | Wang, Fuyi,et al."Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex".JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 14.7(2009):1065-1076. |
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来源：化学研究所
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