Online Purification and Screening of Nisoldipine with a Novel Poly(vinyl ester) Resin Monolithic Column
文献类型：期刊论文
| 作者 | Feng, Xiaojuan1; Liu, Haiyan1; Yang, Gengliang1,2; Ren, Bingnan1; Yang, Xinru1; Yang, Guanqun1 |
| 刊名 | CHROMATOGRAPHIA
 |
| 出版日期 | 2009-03-01 |
| 卷号 | 69期号:5-6页码:403-407 |
| 关键词 | Monolithic Column Vinyl Ester Resin Deproteinization Enrichment Nisoldipine |
| ISSN号 | 0009-5893 |
| DOI | 10.1365/s10337-008-0904-z |
| 英文摘要 | A monolithic column, prepared from a vinyl ester resin used as both monomer and cross-linking agent, has been used to remove matrix compounds from biological fluid. Using this column, nisoldipine in human plasma samples could be enriched online and the protein could be eluted. For this method of extraction, response (peak area) was a linear function of concentration in the range 2-80 ng mL(-1), with a linear regression coefficient of 0.99985. The limit of detection for nisoldipine in plasma was 1.2 ng mL(-1). For nisoldipine at concentrations of 10, 30, and 70 ng mL(-1) RSD were 4.33, 6.63, and 4.57%, respectively. Recovery for both extraction (> 73.6%) and the entire analytical method (> 90.7%) were acceptable for screening of plasma for nisoldipine. The 12-hour pharmacokinetic profile of nisoldipine in mice after oral administration (0.3 mg kg(-1)) was investigated. The results indicated the method could be used for therapeutic monitoring of nisoldipine and enabled simple and rapid assay of the drug in plasma. |
| 语种 | 英语 |
| WOS记录号 | WOS:000263826600001 |
| 出版者 | VIEWEG |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67129]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Gengliang |
| 作者单位 | 1.Hebei Univ, Coll Pharm, Baoding 071002, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Xiaojuan,Liu, Haiyan,Yang, Gengliang,et al. Online Purification and Screening of Nisoldipine with a Novel Poly(vinyl ester) Resin Monolithic Column[J]. CHROMATOGRAPHIA,2009,69(5-6):403-407. |
| APA | Feng, Xiaojuan,Liu, Haiyan,Yang, Gengliang,Ren, Bingnan,Yang, Xinru,&Yang, Guanqun.(2009).Online Purification and Screening of Nisoldipine with a Novel Poly(vinyl ester) Resin Monolithic Column.CHROMATOGRAPHIA,69(5-6),403-407. |
| MLA | Feng, Xiaojuan,et al."Online Purification and Screening of Nisoldipine with a Novel Poly(vinyl ester) Resin Monolithic Column".CHROMATOGRAPHIA 69.5-6(2009):403-407. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。