Multi-morphological biodegradable PLGE nanoparticles and their drug release behavior
文献类型：期刊论文
| 作者 | Zhang, Hanwei; Bei, Jianzhong; Wang, Shenguo |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2009 |
| 卷号 | 30期号:1页码:100-107 |
| 关键词 | Poly(Lactide-co-glycolide)-b-peo-b-Poly(Lactide-co-glycolide) Tri-block coPolymer (Plge) Nanoparticles (Nps) Multi-morphology Csa Drug Delivery |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2008.09.016 |
| 英文摘要 | A series of amphiphilic tri-block copolymers based on poly(lactide-co-glycolide)-b-poly(ethylene oxide)b-poly(lactide-co-glycolide) (PLGE) with various segment ratios of PEO/PLGA and segment lengths of PEO were synthesized. Multi -morphological biodegradable nanoparticles - PLGE-NPs were fabricated by an improved emulsion/solvent evaporation technique in the absence of surfactant. By adjusting segment ratio of PLGA/PEO (w/w) and molecular weight of PEO, various morphological and nanoscale sized spheres, elliptic spheres, short rods and threads could be formed. The auto-assembling mechanism of the PLGE-NPs and influencing effectors of composition of the PLGE on morphology of the PLGE-NPs were discussed. The PLGE-NPs were biodegradable, and the factors that affected the degradation rate of the PLGE-NPs were also discussed. By using the amphiphilic PLGE polymer, the biodegradable nanoscale immunosuppressive agent - multi-morphological Cyclosporine (CsA)-loaded PLGE-NPs was fabricated. CsA release behavior of the CsA-loaded PLGE-NPs in vitro was determined, and the effect factors on CsA release behavior of the CsA-loaded PLGE-NPs were discussed. (C) 2008 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000261139100013 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67317]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Shenguo |
| 作者单位 | Chinese Acad Sci, Inst Chem, BNLMS, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hanwei,Bei, Jianzhong,Wang, Shenguo. Multi-morphological biodegradable PLGE nanoparticles and their drug release behavior[J]. BIOMATERIALS,2009,30(1):100-107. |
| APA | Zhang, Hanwei,Bei, Jianzhong,&Wang, Shenguo.(2009).Multi-morphological biodegradable PLGE nanoparticles and their drug release behavior.BIOMATERIALS,30(1),100-107. |
| MLA | Zhang, Hanwei,et al."Multi-morphological biodegradable PLGE nanoparticles and their drug release behavior".BIOMATERIALS 30.1(2009):100-107. |
入库方式： OAI收割
来源：化学研究所
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