Specific DNA G-Quadruplexes Bind to Ethanolamines
文献类型：期刊论文
| 作者 | Cheng, Xiaohong1,2; Liu, Xiangjun1; Bing, Tao1,2; Zhao, Rui1; Xiong, Shaoxiang1; Shangguan, Dihua1 |
| 刊名 | BIOPOLYMERS
 |
| 出版日期 | 2009-10-01 |
| 卷号 | 91期号:10页码:874-883 |
| 关键词 | G-quadruplexes Molecular Interaction Ethanolamine |
| ISSN号 | 0006-3525 |
| DOI | 10.1002/bip.21272 |
| 英文摘要 | A significant number of G-quadruplex-forming sequences have been revealed in human genome by bioinfomatic searches, implying that G-quadruplexes may be involved in important biological processes and may be new chemotherapeutic targets. Therefore, it is important to discover the potential interactions of G-quadruplexes with other molecules or groups. Here we describe a class of G-quadruplexes, which can bind to ethanolamine groups that widely exist in biomolecules and drug molecules. The specific interaction of these G-quadruplexes with ethanolamine groups was identified by high performance affinity chromatography (HPAC) using immobilized ethanolamine and diethanolamine as stationary phase reagents. The circular dichroism (CD) spectra and native polyacrylamide gel electrophoresis (PAGE) show that these ethanolamine binding quadruplexes adopt an intramolecularly parallel structure. The relationship of ethanolamine binding and G-quadruplexe structure provides new clues for the G-quadruplex-related studies as well as for the molecular designs of therapeutic reagents. (C) 2009 Wiley Periodicals, Inc. Biopolyiners 91: 874-883,2009. |
| 语种 | 英语 |
| WOS记录号 | WOS:000269267500007 |
| 出版者 | JOHN WILEY & SONS INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67495]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Shangguan, Dihua |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Xiaohong,Liu, Xiangjun,Bing, Tao,et al. Specific DNA G-Quadruplexes Bind to Ethanolamines[J]. BIOPOLYMERS,2009,91(10):874-883. |
| APA | Cheng, Xiaohong,Liu, Xiangjun,Bing, Tao,Zhao, Rui,Xiong, Shaoxiang,&Shangguan, Dihua.(2009).Specific DNA G-Quadruplexes Bind to Ethanolamines.BIOPOLYMERS,91(10),874-883. |
| MLA | Cheng, Xiaohong,et al."Specific DNA G-Quadruplexes Bind to Ethanolamines".BIOPOLYMERS 91.10(2009):874-883. |
入库方式： OAI收割
来源：化学研究所
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