One-Pot Multicomponent Synthesis of Azaindoles and Pyrroles from One Molecule of a Silicon-Tethered Diyne and Three or Two Molecules of Organonitriles Mediated by Zirconocene
文献类型：期刊论文
| 作者 | Zhang, Shaoguang1; Sun, Xiaohua1,2; Zhang, Wen-Xiong1; Xi, Zhenfeng1,3 |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2009 |
| 卷号 | 15期号:46页码:12608-12617 |
| 关键词 | Alkynes Cyanides Multicomponent Reactions Nitrogen Heterocycles Zirconium |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.200902411 |
| 英文摘要 | A zirconocene-mediated one-pot multicomponent synthesis process leading to the synthesis of pyrrolo[3,2-c]pyridine (5-azaindoles) and pyrrole derivatives has been developed starting from a silicon-tethered diyne and three or two different or identical organonitriles. Pyrrolo[3,2-c]pyridine and pyrrole derivatives with diverse structures and substitution patterns have been highly selectively prepared by this protocol. A wide variety of organonitriles and silicon-tethered diynes, either aliphatic or aromatic with both electron-withdrawing and -donating groups, have been used to afford 5-azaindoles and/or pyrroles in good-to-excellent isolated yields. A key intermediate formed in the Cp2Zr11-mediated reaction of one (PhC C)(2)SiMe2, two molecules of iPrCN and one p-tolylCN was characterised by Xray single-crystal structural analysis, which has allowed us to gain a good understanding of the reaction process. |
| 语种 | 英语 |
| WOS记录号 | WOS:000272509500012 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67505]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Xi, Zhenfeng |
| 作者单位 | 1.Peking Univ, Coll Chem, Minist Educ, Key Lab Bioorgan Chem & Mol Engn,BNLMS, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shaoguang,Sun, Xiaohua,Zhang, Wen-Xiong,et al. One-Pot Multicomponent Synthesis of Azaindoles and Pyrroles from One Molecule of a Silicon-Tethered Diyne and Three or Two Molecules of Organonitriles Mediated by Zirconocene[J]. CHEMISTRY-A EUROPEAN JOURNAL,2009,15(46):12608-12617. |
| APA | Zhang, Shaoguang,Sun, Xiaohua,Zhang, Wen-Xiong,&Xi, Zhenfeng.(2009).One-Pot Multicomponent Synthesis of Azaindoles and Pyrroles from One Molecule of a Silicon-Tethered Diyne and Three or Two Molecules of Organonitriles Mediated by Zirconocene.CHEMISTRY-A EUROPEAN JOURNAL,15(46),12608-12617. |
| MLA | Zhang, Shaoguang,et al."One-Pot Multicomponent Synthesis of Azaindoles and Pyrroles from One Molecule of a Silicon-Tethered Diyne and Three or Two Molecules of Organonitriles Mediated by Zirconocene".CHEMISTRY-A EUROPEAN JOURNAL 15.46(2009):12608-12617. |
入库方式： OAI收割
来源：化学研究所
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