Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves
文献类型：期刊论文
| 作者 | Li, Qian1,3; Xiang, Junfeng1; Li, Xudong2; Chen, Lirong2; Xu, Xiaojie2; Tang, Yalin1; Zhou, Qiuju1,3; Li, Lin1,3; Zhang, Hong1; Sun, Hongxia1 |
| 刊名 | BIOCHIMIE
 |
| 出版日期 | 2009-07-01 |
| 卷号 | 91期号:7页码:811-819 |
| 关键词 | G-quadruplex Groove Binding Non-planar Alkaloids |
| ISSN号 | 0300-9084 |
| DOI | 10.1016/j.biochi.2009.03.007 |
| 英文摘要 | Human DNA sequences consisting of tandem guanine (G) nucleotides can fold into a four-stranded structure named G-quadruplex via Hoogsteen hydrogen bonding. As the sequences forming G-quadruplex exist in essential regions of eukaryotic chromosomes and are involved in many important biological processes, the study of their biological functions has currently become a hotspot. Compounds selectively binding and stabilizing G-quadruplex structures have the potential to inhibit telomerase activity or alter oncogene expression levels and thus may act as antitumor agents. Most of reported G-quadruplex ligands generally have planar structures which stabilize G-quadruplex by pi-pi stacking. However, based on a pharmacophore-based virtual screening two non-planar G-quadruplex ligands were found. These two ligands exhibit good capability for G-quadruplex stabilization and prefer binding to paralleled G-quadruplex rather than to duplex DNA. The binding of these ligands to G-quadruplex may result from groove binding at a 2:1 stoichiometry. These results have shown that planar structures are not essential for G-quadruplex stabilizers, which may represent a new class of G-quadruplex-targeted agents as potential antitumor drugs. (C) 2009 Elsevier Masson SAS. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000267628700001 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67543]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Tang, Yalin |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci,BNLMS, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China 2.Peking Univ, BNLMS, State Key Lab Rare Earth Mat Chem & Applicat, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qian,Xiang, Junfeng,Li, Xudong,et al. Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves[J]. BIOCHIMIE,2009,91(7):811-819. |
| APA | Li, Qian.,Xiang, Junfeng.,Li, Xudong.,Chen, Lirong.,Xu, Xiaojie.,...&Xu, Guangzhi.(2009).Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves.BIOCHIMIE,91(7),811-819. |
| MLA | Li, Qian,et al."Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves".BIOCHIMIE 91.7(2009):811-819. |
入库方式： OAI收割
来源：化学研究所
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