The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with L-lactic acid oligomer for bone repair
文献类型：期刊论文
| 作者 | Cui, Yang1,2,3; Liu, Yi3; Cui, Yi1; Jing, Xiabin1; Zhang, Peibiao1; Chen, Xuesi1 |
| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2009-09-01 |
| 卷号 | 5期号:7页码:2680-2692 |
| 关键词 | Poly(Lactide-co-glycotide) Grafted Hydroxyapatite Nanoparticles Mechanical Properties Biocompatibility Bone Repair |
| ISSN号 | 1742-7061 |
| DOI | 10.1016/j.actbio.2009.03.024 |
| 英文摘要 | Nanohydroxyapatite (op-HA) surface-modified with L-lactic acid oligomer (LAc oligomer) was prepared by LAc oligomer grafted onto the hydroxyapatite (HA) surface. The nanocomposite of op-HA/PLGA with different op-HA contents of 5, 10, 20 and 40 wt.% in the composite was fabricated into three-dimensional scaffolds by the melt-molding and particulate leaching methods. PLGA and the nanocomposite of HA/PLGA with 10 wt.% of ungrafted hydroxyapatite were used as the controls. The scaffolds were highly porous with evenly distributed and interconnected pore structures, and the porosity was around 90%. Besides the macropores of 100-300 mu m created by the leaching of NaCl particles, the micropores (1-50 mu m) in the pore walls increased with increasing content of op-HA in the composites of op-HA/PLGA. The op-HA particles could disperse more uniformly than those of pure HA in PLGA matrix. The 20 wt.% op-HA/PLGA sample exhibited the maximum mechanical strength, including bending strength (4.14 MPa) and compressive strength (2.31 MPa). The cell viability and the areas of the attached osteoblasts on the films of 10 wt.% op-HA/PLGA and 20 wt.% op-HA/PLGA were evidently higher than those on the other composites. For the animal test, there was rapid healing in the defects treated with 10 and 20 wt.% op-HA/PLGA, where bridging by a large bony callus was observed at 24 weeks post-surgery. There was nonunion of radius defects implanted with PLGA and in the untreated group. This was verified by the Masson's trichrome staining photomicrographs of histological analysis. All the data extrapolated that the composite with 10 and 20 wt.% op-HA exhibited better comprehensive properties and were the optimal composites for bone repairing. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000270636900033 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67569]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, Peibiao |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Grad Sch, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Changchun Cent Hosp, Changchun 130051, Peoples R China 3.Jilin Univ, Hosp 1, Dept Spine Surg, Changchun 130021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Yang,Liu, Yi,Cui, Yi,et al. The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with L-lactic acid oligomer for bone repair[J]. ACTA BIOMATERIALIA,2009,5(7):2680-2692. |
| APA | Cui, Yang,Liu, Yi,Cui, Yi,Jing, Xiabin,Zhang, Peibiao,&Chen, Xuesi.(2009).The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with L-lactic acid oligomer for bone repair.ACTA BIOMATERIALIA,5(7),2680-2692. |
| MLA | Cui, Yang,et al."The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with L-lactic acid oligomer for bone repair".ACTA BIOMATERIALIA 5.7(2009):2680-2692. |
入库方式： OAI收割
来源：化学研究所
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