Optical investigation of diffusion of levofloxacin mesylate in agarose hydrogel
文献类型：期刊论文
| 作者 | Tan, Shuaixia1,2; Dai, Hongjun1,2; Wu, Juejie1,3; Zhao, Ning1; Zhang, Xiaoli1; Xu, Jian1 |
| 刊名 | JOURNAL OF BIOMEDICAL OPTICS
 |
| 出版日期 | 2009-09-01 |
| 卷号 | 14期号:5 |
| 关键词 | Agarose Hydrogel Diffusion Electronic Speckle Pattern Interferometry Levofloxacin Mesylate |
| ISSN号 | 1083-3668 |
| DOI | 10.1117/1.3227034 |
| 英文摘要 | Real-time electronic speckle pattern interferometry method has been applied to study the diffusion behavior of levofloxacin mesylate (MSALVFX) in agarose hydrogel. The results show that the diffusivity of solute decreases with the increase of concentration of agarose and adapts to Kohlrausch's law. Furthermore, Amsden's model, based on the retardance effect associated with polymer chain flexibility, was employed to simulate the diffusion behavior. The consistent results suggest that the retardance effect dominates the diffusion process of MSALFVX in hydrogel; moreover, polymer chain flexibility greatly affects drug transport within the polymer matrix. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3227034] |
| 语种 | 英语 |
| WOS记录号 | WOS:000271746100004 |
| 出版者 | SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67585]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhao, Ning |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100190, Peoples R China 3.Xiangtan Univ, Coll Chem, Xiangtan 411105, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Shuaixia,Dai, Hongjun,Wu, Juejie,et al. Optical investigation of diffusion of levofloxacin mesylate in agarose hydrogel[J]. JOURNAL OF BIOMEDICAL OPTICS,2009,14(5). |
| APA | Tan, Shuaixia,Dai, Hongjun,Wu, Juejie,Zhao, Ning,Zhang, Xiaoli,&Xu, Jian.(2009).Optical investigation of diffusion of levofloxacin mesylate in agarose hydrogel.JOURNAL OF BIOMEDICAL OPTICS,14(5). |
| MLA | Tan, Shuaixia,et al."Optical investigation of diffusion of levofloxacin mesylate in agarose hydrogel".JOURNAL OF BIOMEDICAL OPTICS 14.5(2009). |
入库方式： OAI收割
来源：化学研究所
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