On-line electrochemical measurements of cerebral hypoxanthine of freely moving rats
文献类型：期刊论文
| 作者 | Zhang ZiPin; Lin YuQing; Mao LanQun |
| 刊名 | SCIENCE IN CHINA SERIES B-CHEMISTRY
 |
| 出版日期 | 2009-10-01 |
| 卷号 | 52期号:10页码:1677-1682 |
| 关键词 | On-line Method Electrochemical Biosensor Hypoxanthine Rat Brain |
| ISSN号 | 1006-9291 |
| DOI | 10.1007/s11426-009-0231-8 |
| 英文摘要 | This study demonstrates an on-line method for continuous measurements of cerebral hypoxanthine in the freely moving rats with integration of selective electrochemical biosensing with in vivo microdialysis sampling. The selective electrochemical biosensing is achieved by using xanthine oxidase (XOD) as the specific sensing element and Prussian blue (PB) as the electrocatalyst for the reduction of H(2)O(2) generated from the oxidase-catalyzed reaction. The method is virtually interference-free from the coexisting electroactive species in the brain and exhibits a good stability and reproducibility. Upon integrated with in vivo microdialysis, the on-line method is well suitable for continuous measurements of cerebral hypoxanthine of freely moving rats, which is illustrated by the measurements of the microdialysates after the hypoxanthine standard was externally infused into the rat brain. This study essentially offers a facile on-line electrochemical approach to continuous measurements of cerebral hypoxanthine and could find some interesting applications in physiological and pathological investigations associated with hypoxanthine. |
| 语种 | 英语 |
| WOS记录号 | WOS:000271168500019 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67635]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Mao LanQun |
| 作者单位 | Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang ZiPin,Lin YuQing,Mao LanQun. On-line electrochemical measurements of cerebral hypoxanthine of freely moving rats[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2009,52(10):1677-1682. |
| APA | Zhang ZiPin,Lin YuQing,&Mao LanQun.(2009).On-line electrochemical measurements of cerebral hypoxanthine of freely moving rats.SCIENCE IN CHINA SERIES B-CHEMISTRY,52(10),1677-1682. |
| MLA | Zhang ZiPin,et al."On-line electrochemical measurements of cerebral hypoxanthine of freely moving rats".SCIENCE IN CHINA SERIES B-CHEMISTRY 52.10(2009):1677-1682. |
入库方式： OAI收割
来源：化学研究所
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