Glycyrrhetinic acid-modified nanoparticles for drug delivery: Preparation and characterization
文献类型：期刊论文
| 作者 | Tian Qin1; Wang Wei1; He XiaoTing1; Zhu XiaoCui1; Huang Wei1; Zhang ChuangNian1; Yuan Zhi1; Chen XueSi2 |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2009-09-01 |
| 卷号 | 54期号:18页码:3121-3126 |
| 关键词 | Glycyrrhetinic Acid Chitosan Drug Delivery |
| ISSN号 | 1001-6538 |
| DOI | 10.1007/s11434-009-0249-5 |
| 英文摘要 | In this work, glycyrrhetinic acid-modified chitosan (mGA-suc-CTS) used as liver targeted carrier for drug delivery, was prepared via hemisuccinate as a bridged group. The structure of the product was confirmed by IR and NMR methods and the degree of substitution (DS) of glycyrrhetinic acid groups was estimated via elemental analysis. Nanoparticles were formed by ionic gelation methold. The drug-loading and release behavior of the nanoparticles were investigated using BSA as the model drug. The results indicated that the carrier with a highest DS of 5.19% could be got and the DS was controlled by changing reaction temperature or feed ratio. BSA could be entrapped into the nanoparticles with the drug-loading ratio of 26.3% and the encapsulation efficiency of 81.5%. A sustained release over an 11-day period was observed in pH 7.4 in vitro. |
| 语种 | 英语 |
| WOS记录号 | WOS:000269896500001 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67661]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yuan Zhi |
| 作者单位 | 1.Nankai Univ, Key Lab Funct Polymer Mat, Minist Educ, Inst Polymer Chem, Tianjin 300071, Peoples R China 2.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian Qin,Wang Wei,He XiaoTing,et al. Glycyrrhetinic acid-modified nanoparticles for drug delivery: Preparation and characterization[J]. CHINESE SCIENCE BULLETIN,2009,54(18):3121-3126. |
| APA | Tian Qin.,Wang Wei.,He XiaoTing.,Zhu XiaoCui.,Huang Wei.,...&Chen XueSi.(2009).Glycyrrhetinic acid-modified nanoparticles for drug delivery: Preparation and characterization.CHINESE SCIENCE BULLETIN,54(18),3121-3126. |
| MLA | Tian Qin,et al."Glycyrrhetinic acid-modified nanoparticles for drug delivery: Preparation and characterization".CHINESE SCIENCE BULLETIN 54.18(2009):3121-3126. |
入库方式： OAI收割
来源：化学研究所
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