Chemical crosslinking and biophysical properties of electrospun hyaluronic acid based ultra-thin fibrous membranes
文献类型：期刊论文
| 作者 | Xu, Shanshan1; Li, Junxing1; He, Aihua1,2; Liu, Wenwen3; Jiang, Xingyu3; Zheng, Jianfen1; Han, Charles C.1; Hsiao, Benjamin S.4,5; Chu, Benjamin4,5; Fang, Dufei5 |
| 刊名 | POLYMER
 |
| 出版日期 | 2009-07-17 |
| 卷号 | 50期号:15页码:3762-3769 |
| ISSN号 | 0032-3861 |
| 关键词 | Hyaluronic Acid Electrospinning Crosslinking |
| DOI | 10.1016/j.polymer.2009.06.009 |
| 英文摘要 | Hyaluronic acid (HA) ultra-thin fibrous membranes by electrospinning technology had been fabricated successfully by our group. However, these HA fibrous membranes dissolve and decompose rapidly in water. In this study, chemical crosslinking of HA and HA based ultra-thin fibrous membranes was studied in detail. It was found that the chemically crosslinked pure HA ultra-thin fibrous membranes with 1-ethyl -3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) as the crosslinking agent did not show an obvious improvement in the water-resistance. However, by simply adding and changing the gelatin content, the degradation time of the HA based fibrous membranes could be effectively adjusted from one week to several months. That is with the increase in gelatin content, the water-resistance of the HA/gelatin bi-component membranes could be increased greatly. The crosslinked HA/gelatin bicomponent membranes were evaluated in vitro by seeding with mouse embryonic fibroblasts (3T6-Swiss Albino). The results showed that the HA/gelatin fibrous membranes were cytocompatible and suitable for cell viability. However, cells were hard to attach and grow on the HA based membranes. Thus, the HA/gelatin fibrous membranes with controllable degradation rate could have good potential applications in the anti-adhesion and wound dressing fields. (C) 2009 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000268306700045 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67681]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | He, Aihua |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Joint Lab Polymer Sci & Mat,State Key Lab Polymer, Beijing 100190, Peoples R China 2.Qingdao Univ Sci & Technol, Coll Polymer Sci & Engn, Minist Educ, Key Lab Rubber Plast, Qingdao 266042, Peoples R China 3.Natl Ctr NanoSci & Technol, Beijing 100190, Peoples R China 4.SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA 5.STAR, Stony Brook, NY 11794 USA |
| 推荐引用方式 GB/T 7714 | Xu, Shanshan,Li, Junxing,He, Aihua,et al. Chemical crosslinking and biophysical properties of electrospun hyaluronic acid based ultra-thin fibrous membranes[J]. POLYMER,2009,50(15):3762-3769. |
| APA | Xu, Shanshan.,Li, Junxing.,He, Aihua.,Liu, Wenwen.,Jiang, Xingyu.,...&Fang, Dufei.(2009).Chemical crosslinking and biophysical properties of electrospun hyaluronic acid based ultra-thin fibrous membranes.POLYMER,50(15),3762-3769. |
| MLA | Xu, Shanshan,et al."Chemical crosslinking and biophysical properties of electrospun hyaluronic acid based ultra-thin fibrous membranes".POLYMER 50.15(2009):3762-3769. |
入库方式： OAI收割
来源：化学研究所
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