General Peroxidase Activity of G-Quadruplex-Hemin Complexes and Its Application in Ligand Screening
文献类型：期刊论文
| 作者 | Cheng, Xiaohong1,2; Liu, Xiangjun1; Bing, Tao1,2; Cao, Zehui1; Shangguan, Dihua1 |
| 刊名 | BIOCHEMISTRY
 |
| 出版日期 | 2009-08-25 |
| 卷号 | 48期号:33页码:7817-7823 |
| ISSN号 | 0006-2960 |
| DOI | 10.1021/bi9006786 |
| 英文摘要 | DNA sequences with repetitive G-rich structural motifs, which form special structures called G-quadruplexes, widely exist in the human genome. Here we report the general peroxidase activity of G-quadruplex-hemin complexes and discuss the connection between peroxidase activity and G-quadruplex structures. The high peroxidase activity of hemin complexed with intramolecular parallel G-quadruplex-forming sequences in gene promoters (such as c-Myc, VEGF, c-Kit21, HIF-1 alpha, and RET) may imply a potential mechanism of hemin-mediated cellular injury. This peroxidase activity has also been demonstrated to be applicable for screening G-quadruplex ligands (potential anticancer reagents) using colorimetric and Visual detection strategies. |
| 语种 | 英语 |
| WOS记录号 | WOS:000269044800006 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/67719]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Shangguan, Dihua |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Xiaohong,Liu, Xiangjun,Bing, Tao,et al. General Peroxidase Activity of G-Quadruplex-Hemin Complexes and Its Application in Ligand Screening[J]. BIOCHEMISTRY,2009,48(33):7817-7823. |
| APA | Cheng, Xiaohong,Liu, Xiangjun,Bing, Tao,Cao, Zehui,&Shangguan, Dihua.(2009).General Peroxidase Activity of G-Quadruplex-Hemin Complexes and Its Application in Ligand Screening.BIOCHEMISTRY,48(33),7817-7823. |
| MLA | Cheng, Xiaohong,et al."General Peroxidase Activity of G-Quadruplex-Hemin Complexes and Its Application in Ligand Screening".BIOCHEMISTRY 48.33(2009):7817-7823. |
入库方式： OAI收割
来源：化学研究所
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